<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>Dialysis-requiring acute kidney injury (AKI-D) after cardiac surgery is a major cause of in-hospital mortality. However, the long-term outcome has n...
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https://www.riss.kr/link?id=A107739102
2019
-
SCOPUS,SCIE
학술저널
92-98(7쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>Dialysis-requiring acute kidney injury (AKI-D) after cardiac surgery is a major cause of in-hospital mortality. However, the long-term outcome has n...
<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>Dialysis-requiring acute kidney injury (AKI-D) after cardiac surgery is a major cause of in-hospital mortality. However, the long-term outcome has not been previously examined.</P> <P><B>Materials and methods</B></P> <P>We performed a nationwide, population-based cohort study using the claims data in the Korean National Health Insurance System. Patients who underwent cardiac surgery between 2006 and 2015 were considered.</P> <P><B>Results</B></P> <P>Among 52,983 patients who underwent cardiac surgery, 1261 underwent dialysis postoperatively. During the median follow-up of 3.33 years, the AKI-D group had increased risk of all-cause mortality, end-stage renal disease (ESRD) progression, and risk of developing major adverse cardiovascular events (MACEs). These results remained consistent after multivariable analysis and propensity-score matching. Even after excluding patients who continued dialysis at discharge, the AKI-D group consistently exhibited worse mortality and an increased risk of MACEs compared to the control group. Patients who underwent continuous renal replacement therapy in the AKI-D group exhibited comparable mortality and risk of MACEs but reduced progression to ESRD compared to those who received intermittent renal replacement therapy.</P> <P><B>Conclusions</B></P> <P>AKI-D following cardiac surgery was associated with worse long-term postdischarge mortality and elevated risks of dialysis dependency and MACE development. The outcomes were consistent even in the patients who recovered from the dialysis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We examined the impact of dialysis-requiring AKI following cardiac surgery. </LI> <LI> AKI-D after cardiac surgery is associated with worse long-term prognosis. </LI> <LI> Postdischarge patients who recovered from AKI-D exhibited poor long-term outcomes. </LI> </UL> </P>