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      식품 중 데스메틸시부트라민의 규명 및 분석 = Elucidation and Analysis of Desmethylsibutramine in Food

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      https://www.riss.kr/link?id=A104488395

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      다국어 초록 (Multilingual Abstract)

      It has been elucidated desmethylsibutramine in food, that is an analogue of sibutramine used for anti-obesity drug. After separating and purifying in food samples, it was analyzed and identified by the instrument such as HPLC/PDA, HPLC/MS, HPLC/MS/MS ...

      It has been elucidated desmethylsibutramine in food, that is an analogue of sibutramine used for anti-obesity drug. After separating and purifying in food samples, it was analyzed and identified by the instrument such as HPLC/PDA, HPLC/MS, HPLC/MS/MS and NMR. To analyze sibutamine and desmathylsibutramine in foods, they were analyzed and identified by HPLC/PDA after extracting in dichloromethane, filtering, concentration and diluting in methanol. The overall recoveries were ranged from 87% to 91% and the limit of quantitation was 2.5 μg/kg. As results, sibutramine and desmethylsibutramine was not detected in all the selected 54 food samples.

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      참고문헌 (Reference)

      1 강재헌, "한국인 비만유전체 관련연구" 71-80, 2004

      2 "식품의약품안전청 홈페이지"

      3 "식품공전, 식품의약품안전청"

      4 "세계보건기구 홈페이지"

      5 "살 빼는 약 바로 알고 복용하세요" 식품의약품안전청 2007

      6 Giel, K., "Weight reduction and maintenance in a specialized outpatient health care center" 2 : 143-150, 2008

      7 Slovacek, L., "The effect of sibutramine therapy on occurrence of depression symptoms among obese patients" 18 : e43-e44, 2008

      8 Jeffery, J., "Synthesis of sibutramine, a novel cyclobutylalkylamine useful in the treatment of obesity, and its major human metabolites" 1 : 2583-2590, 1996

      9 Ding, L., "Simultaneous determination of sibutramine and its N-desmethyl metabolites in human plasma by liquid chromatography-electrospray ionization-mass spectrometry: Method and clinical applications" 492 : 241-248, 2003

      10 Simone, G., "Sibutramine: Balancing weight loss benefit and possible cardiovascular risk" 18 : 337-341, 2008

      1 강재헌, "한국인 비만유전체 관련연구" 71-80, 2004

      2 "식품의약품안전청 홈페이지"

      3 "식품공전, 식품의약품안전청"

      4 "세계보건기구 홈페이지"

      5 "살 빼는 약 바로 알고 복용하세요" 식품의약품안전청 2007

      6 Giel, K., "Weight reduction and maintenance in a specialized outpatient health care center" 2 : 143-150, 2008

      7 Slovacek, L., "The effect of sibutramine therapy on occurrence of depression symptoms among obese patients" 18 : e43-e44, 2008

      8 Jeffery, J., "Synthesis of sibutramine, a novel cyclobutylalkylamine useful in the treatment of obesity, and its major human metabolites" 1 : 2583-2590, 1996

      9 Ding, L., "Simultaneous determination of sibutramine and its N-desmethyl metabolites in human plasma by liquid chromatography-electrospray ionization-mass spectrometry: Method and clinical applications" 492 : 241-248, 2003

      10 Simone, G., "Sibutramine: Balancing weight loss benefit and possible cardiovascular risk" 18 : 337-341, 2008

      11 Esposito, P., "Severe Symptomatic Hyponatremia During Sibutramine Therapy: A Case Report, 21" 52 : 137-139, 2008

      12 DeWald, T., "Pharmacological and surgical treatments for obesity" 151 : 604-624, 2006

      13 Eckel, R., "Obesity. in: Mechanisms and clinical management" Lippincott Williams & Wilkins 2003

      14 Haslam, D., "Obesity" 366 : 1197-1209, 2005

      15 Ando, K., "Metabolic syndrome and oxidative stress" 47 : 213-218, 2009

      16 Corbalan, M., "Effectiveness of cognitive– behavioral therapy based on the Mediterranean diet for the treatment of obesity" 25 : 861-869, 2009

      17 James, W., "Effect of sibutramine on weight maintenance after weight loss: a randomised trial" 356 : 2119-2125, 2000

      18 Michand, K., "Chronic glucocorticoid hypersecretion in Cushing’s syndrome exacerbates cognitive aging" 71 : 1-8, 2009

      19 Reedy, S., "An Evidence-Based Review of Obesity and Bariatric Surgery" 5 : 22-29, 2009

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2026 평가예정 재인증평가 신청대상 (재인증)
      2020-01-01 평가 등재학술지 유지 (재인증) KCI등재
      2017-01-01 평가 등재학술지 유지 (계속평가) KCI등재
      2013-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2010-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2009-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2008-01-01 평가 등재후보 1차 FAIL (등재후보1차) KCI등재후보
      2006-07-21 학회명변경 영문명 : The Korean Sociery Of Food Hygiene And Safety -> The Korean Society of Food Hygiene and Safety KCI등재후보
      2006-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.45 0.45 0.48
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.49 0.49 0.726 0.08
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