삼중 주기적 최소곡면 구조가 적용된 마이크로로봇을 통한 효율적 약물전달 시스템 개발

다국어 초록 (Multilingual Abstract)

Drug delivery with a microrobot via remote control under an electromagnetic actuation (EMA) system has received widespread attention due to the enhanced therapeutic efficiency. Therefore, it can be inferred that the drug loading capacity in the microrobot should be maximized. This work reports on the 3D structured microrobot with a triply periodic minimal surface (TPMS) via a Two-Photon Polymerization (TPP) method using 3D laser lithography. The surface area of the TPMS curved surface increases in inverse proportion to the size of the unit cell. In order to endow the untethered control under the electromagnetic fields, we modified the surface of the microrobot with magnetic nanoparticles. Moreover, we fabricated different sizes of the unit cell to optimize the surface area of the structure and the amount of drug-loaded, respectively. Compared with the cube without TPSM pattern, as a control, we demonstrated that TPMS structured microrobot showed considerably improved drug loading capacity