기관지 천식환자의 호염기구로부터의 항원 매개성 히스타민 유리 = 기관지 천식환자의 호염기구로부터의 항원 매개성 히스타민 유리

다국어 초록 (Multilingual Abstract)

Release of chemical mediators in target organs plays an important role to provoke symptoms in allergi dieases. Histamine, one of chemical mediators, exists mostly in mast cells or basophils. Histamine has been used as an indicator for the releasability of chemical mediators in allergic diseases. To evaluate allergen mediated histamine release from basophil of bronchial asthma and observe the relationship between total IgE, skin reactivity, or specific IgE and its releasability, histamine was measured in 27 patients with Dermatophagoides farinae-allergic asthma, 7 patients with intrinsic asthma and 5 normal subjects after challenge with Dermatophagoides farinae (D. farinae, the most common inhalant allergen). Allergen(D, farinae)-madiated histamine release was not observed at any concentration of D. farinae in normal subjects and patients with intrinsic asthma. But Allergen-mediated histamine release was significantly observed in patients with D. farinae- allergic asthma. Allergen-mediated histamine release did not, correlated with skin reractivity and serum total IgE, but correlated significantly with serum D farinae-specific IgE level(p<0.05). Thus allergenmediated histamine release from basophil of bronchial asthmatics was considered to be useful for confirming the offending allergen.