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      KCI등재 SCOPUS

      Study of Single-dose Toxicity of Guseonwangdo-go Glucose Intramuscular Injection in Sprague-Dawley Rats

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      https://www.riss.kr/link?id=A103888983

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      다국어 초록 (Multilingual Abstract)

      Objectives: This study was performed to analyze single-dose intramuscular toxicity of Guseonwangdo-go glucose pharmacopuncture.
      Methods: Eighty six-week-old Sprague-Dawley rats were divided into two large groups of forty rats; Guseonwangdo-go glucose 5% and Guseonwangdo-go glucose 20% groups. Each group was sub-divided into four smaller groups of five males and five females, with the following dosages of pharmacopuncture being administered by intramuscular (IM) injection in each group: group 1 (G1, control group): 1.0 mL of normal saline solution, group 2 (G2, low-dose group): 0.1 mL, group 3 (G3, mid-dose group): 0.5 mL, and group 4 (G4, high-dose group): 1.0 mL.
      Results: No mortalities or clinical signs were observed in any group. Also, no significant changes in body weights or in hematological/biochemical analyses were observed between the control and the experimental groups during necropsy or histopathology.
      Conclusion: The above findings suggest that the lethal dose of Guseonwangdo-go glucose 5% and 20% pharmacopuncture administered via IM injection is more than 1.0 mL per animal in both male and female rats. Further studies on the repeated-dose toxicity of Guseonwangdo-go glucose should be conducted to yield more concrete data.
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      Objectives: This study was performed to analyze single-dose intramuscular toxicity of Guseonwangdo-go glucose pharmacopuncture. Methods: Eighty six-week-old Sprague-Dawley rats were divided into two large groups of forty rats; Guseonwangdo-go glucose...

      Objectives: This study was performed to analyze single-dose intramuscular toxicity of Guseonwangdo-go glucose pharmacopuncture.
      Methods: Eighty six-week-old Sprague-Dawley rats were divided into two large groups of forty rats; Guseonwangdo-go glucose 5% and Guseonwangdo-go glucose 20% groups. Each group was sub-divided into four smaller groups of five males and five females, with the following dosages of pharmacopuncture being administered by intramuscular (IM) injection in each group: group 1 (G1, control group): 1.0 mL of normal saline solution, group 2 (G2, low-dose group): 0.1 mL, group 3 (G3, mid-dose group): 0.5 mL, and group 4 (G4, high-dose group): 1.0 mL.
      Results: No mortalities or clinical signs were observed in any group. Also, no significant changes in body weights or in hematological/biochemical analyses were observed between the control and the experimental groups during necropsy or histopathology.
      Conclusion: The above findings suggest that the lethal dose of Guseonwangdo-go glucose 5% and 20% pharmacopuncture administered via IM injection is more than 1.0 mL per animal in both male and female rats. Further studies on the repeated-dose toxicity of Guseonwangdo-go glucose should be conducted to yield more concrete data.

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      참고문헌 (Reference)

      1 권기록, "靈砂의 急性·亞急性 毒性 및 Sarcoma-180 抗癌效果에 關한 文獻的 硏究" 대한약침학회 6 (6): 39-47, 2003

      2 변부형, "황금약침의 급성독성에 관한 안전성 연구" 대한본초학회 18 (18): 6-51, 2003

      3 Kang KS., "The study on acute and subacute toxicity of Juglandis Semen herbal-acupuncture(JsD)" 4 (4): 85-92, 2001

      4 유창길, "The Study on Acute and Subacute Toxicity and Sarcoma-180 Anti-cancer Effects of Triglii Semen Herbal-acupuncture" 대한약침학회 5 (5): 27-42, 2002

      5 안창석, "The Study on Acute and Subacute Toxicity and Sarcoma-180 Anti-cancer Effects of Carthami Tinctor-Fructus Herbal-acupuncture(CF)" 대한약침학회 5 (5): 7-26, 2002

      6 Kim O, "The Study on Acute and Subacute Toxicity and Sarcoma-180 Anti-cancer Effects of Armeniacaeamarum semen Herbal-Acupuncture (Haeng-In)" 2002

      7 권기록, "The Study on Acute and Subacute Toxicity and Anti-Cancer Effects of cultivated wild ginseng Herbal acupuncture" 대한약침학회 6 (6): 7-27, 2003

      8 "The Daily Records of Royal Secretariat of Joseon Dynasty Internet" National Institute of Korean History

      9 김영진, "Sweet BV의 rat를 이용한 단회 근육시술 독성시험" 대한약침학회 12 (12): 5-32, 2009

      10 Hye-Jeong Lee, "Subchronic oral toxicity of nelumbinis semen in rats and beagle dogs" 경희대학교 대학원 2012

      1 권기록, "靈砂의 急性·亞急性 毒性 및 Sarcoma-180 抗癌效果에 關한 文獻的 硏究" 대한약침학회 6 (6): 39-47, 2003

      2 변부형, "황금약침의 급성독성에 관한 안전성 연구" 대한본초학회 18 (18): 6-51, 2003

      3 Kang KS., "The study on acute and subacute toxicity of Juglandis Semen herbal-acupuncture(JsD)" 4 (4): 85-92, 2001

      4 유창길, "The Study on Acute and Subacute Toxicity and Sarcoma-180 Anti-cancer Effects of Triglii Semen Herbal-acupuncture" 대한약침학회 5 (5): 27-42, 2002

      5 안창석, "The Study on Acute and Subacute Toxicity and Sarcoma-180 Anti-cancer Effects of Carthami Tinctor-Fructus Herbal-acupuncture(CF)" 대한약침학회 5 (5): 7-26, 2002

      6 Kim O, "The Study on Acute and Subacute Toxicity and Sarcoma-180 Anti-cancer Effects of Armeniacaeamarum semen Herbal-Acupuncture (Haeng-In)" 2002

      7 권기록, "The Study on Acute and Subacute Toxicity and Anti-Cancer Effects of cultivated wild ginseng Herbal acupuncture" 대한약침학회 6 (6): 7-27, 2003

      8 "The Daily Records of Royal Secretariat of Joseon Dynasty Internet" National Institute of Korean History

      9 김영진, "Sweet BV의 rat를 이용한 단회 근육시술 독성시험" 대한약침학회 12 (12): 5-32, 2009

      10 Hye-Jeong Lee, "Subchronic oral toxicity of nelumbinis semen in rats and beagle dogs" 경희대학교 대학원 2012

      11 Lee HJ., "Study for the toxicity of kinds of ginseng radix aqua-acupuncture extract" 10 (10): 167-173, 1993

      12 Kim HS., "Studies on the skin test, subcutaneous and muscle Irritation test, and antigenicity test of Salviae radix extract for herb-acupuncture" 11 (11): 25-48, 1994

      13 Jin JP., "Manbyeonghwechun" Bubin publishers 233-, 2007

      14 "Korea Food and Drug Administration. Guidelines for toxicity tests of drugs and related materials (KFDA Notification No. 2012-86)" The National Legal Information Center of the Ministry of Government Legislation

      15 "Korea Food and Drug Administration. Good laboratory practice regulation for non-clinical laboratory studies (KFDA Notification No. 2012-61" The National Legal Information Center of the Ministry of Government Legislation

      16 Kim YS., "Experimental studies on the safety of whangryunhaedok-tang extract solution for herbopuncture" 20 (20): 54-62, 1999

      17 Youn KS., "Experimental studies on the safety of Ephedrae Herba extract solution used for herbal-acupuncture" 14 (14): 361-382, 1997

      18 Soh KS., "Experimental studies on the acute toxicity of Bostaurus, Urusthibetanus extract solution(BU)for herbal-acupuncture" 4 (4): 69-83, 2001

      19 Soh, Kyung-Sun, "Experimental studies on the Acute Toxicity of Bos taurus.Ursus thibetanus.Moschus extrct solution(BUM) for Herbal-acupuncture" 대한약침학회 5 (5): 6-24, 2002

      20 Ju YS., "Effects of Kuseonwangdogo on the proliferation of preadipocyte 3T3-L1 cells, the anti-complementary and the cytotoxic effects" 20 (20): 105-114, 2000

      21 Heo J., "DonguiBogam" Donguibogam publishers Co 1238-1241, 2005

      22 Hwang DY., "Bangyak Happyeon" Younglimsa 137-, 2002

      23 Lim SBN., "Acute toxicity of aqua-acupuncture with houttuyniaeherba in mice and rats" 1 (1): 106-117, 1995

      24 Lim SI., "A study on safety of scolopendrid aqua-acupuncture" 2003

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2016-01-01 평가 등재학술지 선정 (계속평가) KCI등재
      2015-12-01 평가 등재후보로 하락 (기타) KCI등재후보
      2013-08-01 학술지명변경 한글명 : 대한약침학회지 -> Journal of Pharmacopuncture KCI등재
      2011-01-01 평가 등재 1차 FAIL (등재유지) KCI등재
      2010-05-13 학술지명변경 외국어명 : 미등록 -> Journal of Pharmacopuncture KCI등재
      2008-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2007-07-06 학회명변경 영문명 : Korean Institute of Herbal Acupuncture -> Korean Pharmacopuncture Institute KCI등재후보
      2007-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2005-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.2 0.2 0.27
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.28 0.29 0.429 0.05
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