Retrospective study for determining recommended resection margin of neurofibroma = Retrospective study for determining recommended resection margin of neurofibroma

다국어 초록 (Multilingual Abstract)

Background: Cutaneous neurofibroma (CNF) is a common benign tumor. Surgical intervention is currently the best treatment option for the cosmetically disfiguring appearance. Presently, there are a few guidelines for determining adequate surgical margins in literature.
Objectives: This study aims to evaluate the resection margin of CNF and correlation between size of CNF and recommended margin. CNF is difficult to determine the margin visually. Therefore, study based on the size and histological findings of neurofibroma are needed to determine the resection margin.
Methods: From January 2016 to July 2020 were 52 cases of CNF identified in the database of the Dept. of Dermatology at Korea University Ansan Hospital. Lesions were removed surgically with a margin of 3 mm from the clinical delineation. Tumor invasion was evaluated through histopathologic evaluation.
Results: Among the 52 cases of CNF, 24 cases (46%) had a size of 1cm or more and 28 cases (54%) had a size of 1cm or less. 44 lesions (85%) were completely removed without involvement of the margin. Among the 8 cases of incompletely resected CNF, 3 cases involved both side of margin and 5 cases involved one side of margin. Interestingly, none of the cases of CNFs smaller than 1cm were incompletely resected.
Conclusion: In this study, we found that CNF size should be considered when determining the resection margin. For CNFs <1cm in diameter, 3mm resection margins are mostly adequate; but for larger CNFs, greater margins are required.