Gastro-protective effects of Brassica oleracea var. capitata extracts in HCl-Ethanol Induced gastritis rat model

다국어 초록 (Multilingual Abstract)

The purpose of this study was to evaluate the gastro-protective effect of cabbage extract (sulforaphane content was 5.19 mg/L and S-methylmethionine was 469.28 μg/L). In vitro study, the lipopolysaccharide (LPS)-treated group had an increased nitic oxide (NO) and interleukin (IL)-6 activity compared to normal group, and NO and IL-6 level was decreased when the cabbage extract was treated in the manner of dose. In the gastritis-induced mice group, severe hemorrhagic mucosal damage was observed in the entire area of the stomach due to bleeding marks. The degree of gastric mucosal damage was decreased in dose dependent manner. Mucosal erosion in the gastritis model was also ameliorated in the cabbage extract administration group. The blood level of histamine was significantly increased in the gastritis-induced animal model, and the secretion of histamine was reduced in the 23 mg/L treated group of cabbage extract. In conclusion, cabbage extract can help inhibit gastrointestinal disorders by improving the protective barrier. This research was funded by Leading Technology Development Project based on 4th Industrial Revolution from Chungcheongbuk-do.