압출-구형화 공정에 의한 공형과립제도의 제영향인자 검토 (제1보) = Effects of Some Factors on the Preparation of Spherical Particles by Extrusion-spheronization Processing. I

다국어 초록 (Multilingual Abstract)

Extrusion-spheronization processing combination was used to produce spherical granules with experimental formulations which contain microcrystalline cellulose as a diluent. The produced granules were compared on the basis of the following physical properties; (a) particle size distribution, (b) repose angle, (c) granule density, (d) bulk density, (e) porosity, (f) friability and (g) dissolution rate. With the specific experimental formulations used in this study, the increased plate rotational speeds of Marumerizer (400-1200rpm) produced continually more spherical material and also the obtained data indicated that the particle size distribution and dissolution rate depend upon the amount of microcrystalline cellulose used. As a result, the spherical granule preparation with microcrystalline cellulose has good properties in flow rate, packing property and friability and offers a suitable method of granule preparation in pharmaceutical industry.