타액의 프롤린 풍부 단백질에 대한 최신 연구 동향 = Recent Advances in Salivary Proline-Rich Proteins Research

다국어 초록 (Multilingual Abstract)

Although the salivary proteins are relatively small in amount compared to blood serum, they form complexes containing mucins, proline-rich proteins(PRPs), statherin, cystatin, and different antimicrobial proteins. These salivary complexes are stable for a while in whole saliva, which are rich in proteolytic enzymes derived from numerous oral bacteria. Among different salivary proteins, PRPs play important roles for lubrication and protective barrier formation on oral mucosal, anti-caries effect on tooth surface, neutralization of tannin in food, and anti-microbial and anti-viral effects.
PRPs appear as diverse forms, acidic, basic, and glycosylated PRPs, which play various roles depending on foods, bacterial and viral agents, and other oral environments. They also show characteristic DNA polymorphism which may undergo hereditary transmission via the selection to overcome inappropriate conditions. Nevertheless, salivary protein research has not been advanced compared to other fields of human organs, particularly for the investigation of PRPs. This study is to review the recent research progress of alivary PRPs reported in the literatures until 2018.