Biomaterial-Based Tissue Engineering for Tooth-Supportive Complex Regeneration

국문 초록 (Abstract)

조직공학은 질병이나 사고등으로 인해 손상된 조직을 대체하는 인공 보철물 개발에서 자기 조직으로의 재생과 성장을 통해, 본래의 생리학적 기능 회복을 이끄는 재생의학으로 발전해왔다. 줄기세포등을 주입하여 재생을 이끄는 기술을 비롯해, 다양한 단백질과 성장인자들을 전달하여 손상 조직이나 장기를 복원하는 기술들이 개발되면서 조직공학 및 재생의학은 새로운 패러다임을 만들어가고 있다. 특히, 치아를 지지하는 치주조직의 재생은 수백 마이크론단위의 공간내에 특정 방향성을 지닌 섬유결합조직이 골조직과 융합하여 치아를 단단히 지지하는 복합구조를 지니고 있어, 기존의 재생술식으로는 한계가 있다. 이를 극복하고 백악질-치주인대-골조직으로 구성된 치주복합조직의 재생을 유도하기위해, 천연 및 합성 생체고분자재료를 기반으로한 다양한 의공학적 접근법들이 최근 소개되고 있다. 본고에서는 생체재료가 지니는 생물학적 특성을 기반한 치주조직재생유도 구조체 개발의 최신 연구개발 현황 및 전망을 기술하였다.

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