Te Diagnosis and Treatment of Autoimmune Encephalitis

다국어 초록 (Multilingual Abstract)

Autoimmune encephalitis causes subacute defcits of memory and cognition, ofen followed by suppressed level of consciousness or coma. A careful history and examination may show early clues to particular autoimmune causes, such as neuromyotonia, hyperekplexia, psychosis, dystonia, or the presence of particular tumors. Ancillary testing with MRI and EEG may be helpful for excluding other causes, managing seizures, and, rarely, for identifying characteristic fndings. Appropriate autoantibody testing can confrm specifc diagnoses, although this is ofen done in parallel with exclusion of infectious and other causes. Autoimmune encephalitis may be divided into several groups of diseases: those with pathogenic antibodies to cell surface proteins, those with antibodies to intracellular synaptic proteins, T-cell diseases associated with antibodies to intracellular antigens, and those associated with other autoimmune disorders. Many forms of autoimmune encephalitis are paraneoplastic, and each of these conveys a distinct risk profle for various tumors. Tumor screening and, if necessary, treatment is essential to proper management. Most forms of autoimmune encephalitis respond to immune therapies, although powerful immune suppression for weeks or months may be needed in difcult cases. Autoimmune encephalitis may relapse, so follow-up care is important.

참고문헌 (Reference)

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