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      KCI등재후보

      재조합 인슐린 치료 중 발생한 혈중 인슐린농도의 비정상적 상승 증례에 대한 고찰 = Unusually Elevated Serum Insulin Level in a Diabetic Patient during Recombinant Insulin Therapy

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      https://www.riss.kr/link?id=A101598684

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      다국어 초록 (Multilingual Abstract)

      Herein, we report a case of unusually elevated serum insulin level as a result of increased anti-insulin antibody (IA)-bound insulin after continuous subcutaneous insulin infusion therapy. Detecting free insulin (unbound IAs) levels after polyethylene glycol pre-treatment could be useful to assess functional insulin levels in diabetic patients receiving insulin therapy. The E170 insulin assay can estimate total insulin (bound IAs and free insulin) levels, but it does not measure the levels of exogenous insulin analogues.
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      Herein, we report a case of unusually elevated serum insulin level as a result of increased anti-insulin antibody (IA)-bound insulin after continuous subcutaneous insulin infusion therapy. Detecting free insulin (unbound IAs) levels after polyethylene...

      Herein, we report a case of unusually elevated serum insulin level as a result of increased anti-insulin antibody (IA)-bound insulin after continuous subcutaneous insulin infusion therapy. Detecting free insulin (unbound IAs) levels after polyethylene glycol pre-treatment could be useful to assess functional insulin levels in diabetic patients receiving insulin therapy. The E170 insulin assay can estimate total insulin (bound IAs and free insulin) levels, but it does not measure the levels of exogenous insulin analogues.

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      참고문헌 (Reference)

      1 Sapin R., "The interference of insulin antibodies in insulin immunometric assays" 40 : 7058-, 2002

      2 김세림, "The Effects of Anti-insulin Antibodies and Cross-reactivity with Human Recombinant Insulin Analogues in the E170 Insulin Immunometric Assay" 대한진단검사의학회 31 (31): 22-29, 2011

      3 Hanning I, "Measurement of free insulin concentrations: the influence of the timing of extraction of insulin antibodies" 28 : 8315-, 1985

      4 Sapin R., "Insulin assays: previously known and new analytical features" 49 : 11321-, 2003

      5 Kim MR, "Insulin antibodies and hypoglycemia in diabetic patients. Can a quantitative analysis of antibody binding predict the risk of hypoglycemia?" 6 : 28591-, 1997

      6 Fineberg SE, "Immunological responses to exogenous insulin" 28 : 62552-, 2007

      7 Jeandidier N, "Immunogenicity of intraperitoneal insulin infusion using programmable implantable devices" 38 : 57784-, 1995

      8 Koyama R, "Hypoglycemia and hyperglycemia due to insulin antibodies against therapeutic human insulin: treatment with double filtration plasmapheresis and prednisolone" 329 : 25964-, 2005

      9 Arnqvist H, "Free and total insulin as determined after precipitation with polyethylene glycol: analytical characteristics and effects of sample handling and storage" 33 : 936-, 1987

      10 Owen WE, "Crossreactivity of three recombinant insulin analogs with five commercial insulin immunoassays" 50 : 2579-, 2004

      1 Sapin R., "The interference of insulin antibodies in insulin immunometric assays" 40 : 7058-, 2002

      2 김세림, "The Effects of Anti-insulin Antibodies and Cross-reactivity with Human Recombinant Insulin Analogues in the E170 Insulin Immunometric Assay" 대한진단검사의학회 31 (31): 22-29, 2011

      3 Hanning I, "Measurement of free insulin concentrations: the influence of the timing of extraction of insulin antibodies" 28 : 8315-, 1985

      4 Sapin R., "Insulin assays: previously known and new analytical features" 49 : 11321-, 2003

      5 Kim MR, "Insulin antibodies and hypoglycemia in diabetic patients. Can a quantitative analysis of antibody binding predict the risk of hypoglycemia?" 6 : 28591-, 1997

      6 Fineberg SE, "Immunological responses to exogenous insulin" 28 : 62552-, 2007

      7 Jeandidier N, "Immunogenicity of intraperitoneal insulin infusion using programmable implantable devices" 38 : 57784-, 1995

      8 Koyama R, "Hypoglycemia and hyperglycemia due to insulin antibodies against therapeutic human insulin: treatment with double filtration plasmapheresis and prednisolone" 329 : 25964-, 2005

      9 Arnqvist H, "Free and total insulin as determined after precipitation with polyethylene glycol: analytical characteristics and effects of sample handling and storage" 33 : 936-, 1987

      10 Owen WE, "Crossreactivity of three recombinant insulin analogs with five commercial insulin immunoassays" 50 : 2579-, 2004

      11 Radermecker RP, "Circulating insulin antibodies: influence of continuous subcutaneous or intraperitoneal insulin infusion, and impact on glucose control" 25 : 491501-, 2009

      12 Sapin R, "Antiinsulin antibodies in insulin immunometric assays: a still possible pitfall" 35 : 3657-, 1997

      13 Hara K, "Antibodymediated insulin resistance treated by cessation of insulin administration" 39 : 1435-, 2000

      14 Cao Y, "A sensitive chemiluminescent enzyme immunoassay for the bioanalysis of carboxylterminal Bchain analogues of human insulin" 26 : 5361-, 2001

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      공동연구자 (7)

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2027 평가예정 재인증평가 신청대상 (재인증)
      2021-01-01 평가 등재학술지 유지 (재인증) KCI등재
      2018-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2015-01-01 평가 등재학술지 선정 (계속평가) KCI등재
      2013-01-01 평가 등재후보학술지 유지 (기타) KCI등재후보
      2012-01-01 평가 등재후보학술지 유지 (기타) KCI등재후보
      2011-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2011-01-01 평가 학술지 분리 (기타) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.16 0.16 0.11
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.09 0.09 0.306 0.05
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