자궁경부암에서 Phospholipase C-γ1 의 과발현 = Overexpression of phospholipase C-γ1 in cervical neoplasm

다국어 초록 (Multilingual Abstract)

Phospholipase C isozymes(PLCs), which catalyzes the hydrolysis of inositol phospholipids to generate diacylglycerol and inositol 1, 4, 5-triphosphate, play a central role in the signal trnasduction pathway by regulating various cellular processes including cell to cell communication, proliferation and differentiation. Although exact role of PLCs needs further investigation, their biological significance has been suggested in several pathological states such as cancer. In this study, immunohistochemical analysis reveals considerably overexpression of PLC-γ1 in the majority of cervical neoplasm when compared to benign pathological condition except decidual polyp. Therefore, the overexpression of PLC-γ1 in cervical neoplasm suggests that PLC-γ1 mediated signal transduction pathway may be involved in the tumorigenesis or progress of cervical cancer.

목차 (Table of Contents)

• Ⅰ. 서 론
• Ⅱ. 실험방법
• Ⅲ. 결 과
• Ⅳ. 토 의
• Ⅴ. 결 론
• 참고문헌
• Abstract