A case of iatrogenic Kaposi`s sarcoma developed in a psoriasis patient after treatment with immunosuppressive agent = A case of iatrogenic Kaposi`s sarcoma developed in a psoriasis patient after treatment with immunosuppressive agent

다국어 초록 (Multilingual Abstract)

Kaposi’s sarcoma (KS) is a multifocal proliferative vascular neoplasm commonly associated with human immunodeficiency virus infection or immunosuppressive agent. Iatrogenic KS can be developed after long-term treatment with immunosuppressive agents for autoimmune diseases or after solid organ transplantation. A 69-year-old man presented with multiple purplish brown colored macules and patches on both lower legs for two months. Skin biopsy showed vascular proliferation with bland spindle cells in a dermis and immunohistochemical staining for CD31, D2-40 and human herpesvirus-8 were positive. He was diagnosed as KS based on the histologic findings. We noticed he had a 10-year history of nummular type psoriasis treated with several systemic immunosuppressive agents including cyclosporine, methylprednisolone and azathioprine. Therefore, it was assumed that long-term use of immunosuppressive drugs could be the cause of iatrogenic KS in this patient. The lesions were improved by cryotherapy in addition to dose-reduction of cyclosporine. To our knowledge, this is the first report of iatrogenic KS developed in psoriasis patient treated with immunosuppressive agents. Not only transplantation surgeon or rheumatologist but also dermatologist should be aware of the possible occurrence of iatrogenic KS when treating patients with immunosuppressive agents.