Cellular chaperones that belong to the heat‐shock protein 90 (Hsp90) family are a prerequisite for successful viral propagation for most viruses. The hepatitis C virus (HCV) uses Hsp90 for maturation, folding, and modification of viral proteins....
http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
https://www.riss.kr/link?id=O118947771
2019년
-
1860-7179
1860-7187
SCOPUS;SCIE
학술저널
334-342 [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Cellular chaperones that belong to the heat‐shock protein 90 (Hsp90) family are a prerequisite for successful viral propagation for most viruses. The hepatitis C virus (HCV) uses Hsp90 for maturation, folding, and modification of viral proteins....
Cellular chaperones that belong to the heat‐shock protein 90 (Hsp90) family are a prerequisite for successful viral propagation for most viruses. The hepatitis C virus (HCV) uses Hsp90 for maturation, folding, and modification of viral proteins. Based on our previous discovery that marine alkaloid analogues with a 4,5,6,7‐tetrahydrobenzo[1,2‐d]thiazole‐2‐amine structure show inhibition of HCV replication and binding to Hsp90, a series of twelve novel compounds based on this scaffold was designed and synthesized. The aim was improved Hsp90 affinity and anti‐HCV activity. Through structural optimization, improved binding to Hsp90 and specific HCV inhibition in genotype 1b and 2a replicon models was achieved for three compounds belonging to the newly synthesized series. Furthermore, these compounds efficiently inhibited replication of full‐length HCV genotype 2a in a reporter virus RNA assay with IC50 values ranging from 0.03 to 0.6 μm.
New compounds going viral: Twelve compounds were designed and synthesized based on the 4,5,6,7‐tetrahydrobenzo[1,2‐d]thiazole‐2‐amine scaffold. The aim was to achieve antiviral activity against hepatitis C virus (HCV) by targeting Hsp90, a cellular protein essential for HCV propagation. Improved binding to Hsp90β was accomplished and compounds 2, 5, and 8 were found to inhibit replication of full‐length HCV genotype 2a with IC50 values of 0.03 μm (5), 0.1 μm (8), and 0.6 μm (2).
Imidazolidinones and Imidazolidine‐2,4‐diones as Antiviral Agents