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      Individual differences in the engagement of habitual control over alcohol seeking predict the development of compulsive alcohol seeking and drinking

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      https://www.riss.kr/link?id=O107944711

      • 저자
      • 발행기관
      • 학술지명
      • 권호사항
      • 발행연도

        2021년

      • 작성언어

        eng

      • Print ISSN

        1355-6215

      • Online ISSN

        1369-1600

      • 등재정보

        SCIE;SCOPUS

      • 자료형태

        학술저널

      • 원정보자원

        Addiction biology

      • 수록면

        n/a-n   [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]

      • 구독기관
        • 전북대학교 중앙도서관  
        • 성균관대학교 중앙학술정보관  
        • 부산대학교 중앙도서관  
        • 전남대학교 중앙도서관  
        • 제주대학교 중앙도서관  
        • 중앙대학교 서울캠퍼스 중앙도서관  
        • 인천대학교 학산도서관  
        • 숙명여자대학교 중앙도서관  
        • 서강대학교 로욜라중앙도서관  
        • 계명대학교 동산도서관  
        • 충남대학교 중앙도서관  
        • 한양대학교 백남학술정보관  
        • 이화여자대학교 중앙도서관  
        • 고려대학교 도서관  
      • ⓒ COPYRIGHT THE BRITISH LIBRARY BOARD: ALL RIGHT RESERVED
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      다국어 초록 (Multilingual Abstract)

      Excessive drinking is an important behavioural characteristic of alcohol addiction, but not the only one. Individuals addicted to alcohol crave alcoholic beverages, spend time seeking alcohol despite negative consequences and eventually drink to intox...

      Excessive drinking is an important behavioural characteristic of alcohol addiction, but not the only one. Individuals addicted to alcohol crave alcoholic beverages, spend time seeking alcohol despite negative consequences and eventually drink to intoxication. With prolonged use, control over alcohol seeking devolves to anterior dorsolateral striatum, dopamine‐dependent mechanisms implicated in habit learning and individuals in whom alcohol seeking relies more on these mechanisms are more likely to persist in seeking alcohol despite the risk of punishment. Here, we tested the hypothesis that the development of habitual alcohol seeking predicts the development of compulsive seeking and that, once developed, it is associated with compulsive alcohol drinking. Male alcohol‐preferring rats were pre‐exposed intermittently to a two‐bottle choice procedure and trained on a seeking–taking chained schedule of alcohol reinforcement until some individuals developed punishment‐resistant seeking behaviour. The associative basis of their seeking responses was probed with an outcome‐devaluation procedure, early or late in training. After seeking behaviour was well established, subjects that had developed greater resistance to outcome devaluation (were more habitual) were more likely to show punishment‐resistant (compulsive) alcohol seeking. These individuals also drank more alcohol, despite quinine adulteration, even though having similar alcohol preference and intake before and during instrumental training. They were also less sensitive to changes in the contingency between seeking responses and alcohol outcome, providing further evidence of recruitment of the habit system. We therefore provide direct behavioural evidence that compulsive alcohol seeking emerges alongside compulsive drinking in individuals who have preferentially engaged the habit system.
      Individual differences in the development of insensitivity to devaluation of the seeking outcome predict the subsequent development of compulsive alcohol seeking. Once established, compulsive alcohol seeking is insensitive to degradation of the contingency between seeking and taking outcomes. The development of compulsive alcohol seeking is not preceded or predicted by a higher level of alcohol intake. However, once established, it is associated with an escalation of free alcohol intake and insensitivity to adulteration of alcohol with quinine.

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