선천성기형 10년 6개월 연구 ( 1967.1 - 1977.7 ) = Congenital Anomaly, 103 cases in a Ten and Half Year Period

다국어 초록 (Multilingual Abstract)

The data to be presented are based on the 103 cases of congenital anomalies among 19054 newborns delivered after 20 weeks gestation during a 10 and half year period lasting from January 1, 1967 to july 31, 1977 at Ewha Womans University Hospital. This paper will be mainly discussed the types of congenital anomaly,the possible etiologic factors and the ingestion of drugs during firing first trimester pregnancy. The main types of congenital anomalies were found to be 24 cases of anencephalus, 13 congenital heart disease, 7 cleft palate, 7 polyps of ear region, 6 Imperforated Anus, 6 Downs Syndrome, 5 Polydactylism, 3 Omphalocele and 32 others. The over all incidences of congenital anomaly were 103 cases(0l54%) among 19054 new borns of total deliveries. The sex ratios between anomaly and normal gravida showed no any differences. The incidence of congential anomaly in stillbirth was 3.7% which was 9 folds higher than that of live births. The incidence of congentital anomaly in the low birth weight less than 2500gm was 1.9% which was 4 times that in the matured babies. The congenital anoma has occured more often in the women with 4 or more parities(1.23%) in comparision with nullipara or gravidas with one to three parities. The incidence of breech presentation in congenital anomaly was very high compared to those innormal newborns. particularly, it was 7 folds the control group in the anomalies associate with anenccephaly and spina bifida. In reviewing the all mothers 12% of all the mothers had the history of spontaneous abortion and 5% had stillbirths and /or neonatal deaths in the past which were considered very high, three times the normal group. 1.9% of all the mothers who currently delivered anomalous infants had also been experieced previously of congenital anomalies. Approximately one third(28%) of the mothers who delivered congenital anomaly have been taken various medicines including herb drugs(1.38 kinds of drug per gravida) during the first trimester of pregnancy. The ingestion of herbproved that some drugs listed below were one of the most frequently taken in the anomalous group compared to normal control group. mothers with anomaly mothers in control group drugs taken 12.6% 9.1% herb drugs 3.8% 0.5% medicine for cold 3.0% 1.1% sadative & narcotics 3.8% 0.8% Analgesics 2% 0.5% Anti-helminthics 2% 0% Oral Contraceptives 1% 0% Corticosteroids 1% 0.3% Antituberculous agents On the contrary, drugs listed below were more frequently taken in normal control group of mothers than in anomalous group inthe rate of control anomaly drugtaken 7.7% 3.0% digestints 2.8% 1% drugs used for preventing abortion 1.5% 0% beverage A pregnant woman who had been suffered from acute CO gas intoxiccation during her first trimester pregnancy unfortunatly resulted in 43 weeks prolonged pregnancy and consequently delivered an anencephalic infant.