Malignant Inflammatory Myofibroblastic Tumor of the Bladder with Rapid Progression

다국어 초록 (Multilingual Abstract)

A 71-year-old man was referred for painless hematuria and a bladder tumor. Cystoscopy and computed tomography revealed a 3-cm oval nodular mass on the left lateral side of the bladder. The patient underwent a complete transurethral resection of the lesion and histology showed a proliferation of atypical spindle cells with inflammation consistent with a myofibroblastic tumor. After 4 and 7 months, follow-up cystoscopy demonstrated nodular mass lesions and transurethral resection of bladder tumor was done, which showed chronic cystitis and a recurred myofibroblastic tumor, respectively. Five months later, multiple lymph node, bone, and soft tissue metastases were found by positron emission tomography. The patient was treated first with palliative chemotherapy, including doxorubicin and cisplatin. After that, radiologic studies showed disease progression but the patient refused further treatment and died 6 months later.

참고문헌 (Reference)

1 Yamamoto H, "p53 Mutation and MDM2 amplification in inflammatory myofibroblastic tumours" 42 : 431-439, 2003

2 Dishop MK, "Successful treatment of inflammatory myofibroblastic tumor with malignant transformation by surgical resection and chemotherapy" 25 : 153-158, 2003

3 Roth JA, "Reactive pseudosarcomatous response in urinary bladder" 16 : 635-637, 1980

4 Young RH, "Pseudoneoplastic lesions of the urinary bladder and urethra: a selective review with emphasis on recent information" 14 : 133-146, 1997

5 Fujiwara T, "Inflammatory pseudotumor of the bladder: MR findings" 23 : 558-561, 1999

6 Montgomery EA, "Inflammatory myofibroblastic tumors of the urinary tract: a clinicopathologic study of 46 cases, including a malignant example inflammatory fibrosarcoma and a subset associated with high-grade urothelial carcinoma" 30 : 1502-1512, 2006

7 Lu CH, "Huge pelvi-abdominal malignant inflammatory myofibroblastic tumor with rapid recurrence in a 14-year-old boy" 16 : 2698-2701, 2010

8 Coffin CM, "Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases" 19 : 859-872, 1995

9 Li HB, "Diagnostic puzzle of inflammatory pseudotumor of the urinary bladder: a case report with brief literature review" 103 : 563-566, 2010

10 Arber DA, "Detection of Epstein-Barr virus in inflammatory pseudotumor" 15 : 155-160, 1998