보조생식술을 시행한 난임환자에서의 뜸 치료에 대한 체계적 문헌고찰 및 메타분석 = The Effectiveness of Moxibustion Treatment In infertility with IVF-ET : A Systematic Review and Meta-Analysis

다국어 초록 (Multilingual Abstract)

Objectives: The purpose of this study is to investigate the effectiveness of moxibustion in infertility with In Vitro Fertilization and Embryo Transfer (IVF-ET).
Methods: We searched 8 databases (Embase, PubMed, CiNii, CNKI, OASIS, ScienceOn, KMBASE, KISS)to identify eligible studies published before 2021 Oct. We included randomized controlled clinical trials (RCTs) using moxibustion in infertility with IVF-ET. The methodological quality of each RCT was assessed by the Cochrane risk of bias tool.
Results: Two RCT studies were eligible in our review. The overall risk of bias was evaluated as unclear. The meta-analysis of 2 trials indicated that favorable results for the use of moxibustion with IVF-ET.
Conclusions: This systematic review and meta-analysis of clinical trials suggests that moxibustion with IVF-ET can effect on Infertility patients. However, because of studies included analysis was biased due to unclear risk of bias and unreliable study design, future RCT studies and additional Meta-Analysis are needed to judge the supplementary treatment role of moxibustion in infertility with IVF-ET.

참고문헌 (Reference)

1 이미주 ; 손성세 ; 박승혁 ; 박경선 ; 황덕상 ; 이진무 ; 장준복 ; 이창훈, "체외 수정과 한약 치료 중재에 대한 임상연구 동향 - Pubmed를 중심으로 -" 대한한방부인과학회 31 (31): 89-109, 2018

2 최영민 ; 이원돈 ; 강인수 ; 권혁찬 ; 김선행 ; 노성일 ; 문신용 ; 문화숙 ; 민응기 ; 윤태기 ; 이규섭 ; 이상훈 ; 이여일 ; 이정호 ; 전상식 ; 한혁동 ; 황경주 ; 황정혜 ; 김기철, "조사보고서 한국 보조생식술의 현황: 2007년" 대한산부인과학회 53 (53): 1052-1077, 2010

3 남은영 ; 유수정 ; 김형준, "제천시 한방 난임 치료 지원 사업에 관한 연구" 대한한방부인과학회 28 (28): 120-132, 2015

4 이혜인 ; 박경선 ; 유정은 ; 이진무 ; 백선은 ; 이호정, "원발성 월경곤란증의 뜸 치료에 대한 체계적 문헌고찰 및 메타분석" 대한한방부인과학회 30 (30): 107-119, 2017

5 김동일, "보조생식술의 부가적 요법으로서의 한의학적 치료" 대한한방부인과학회 23 (23): 67-79, 2010

6 배경미 ; 조혜숙 ; 이승환 ; 이인선, "보조생식술에 있어서 침의 중재에 대한 임상연구 동향 - Pubmed를 중심으로 -" 대한한방부인과학회 22 (22): 65-82, 2009

7 Huang B, "艾灸在女性不孕患者体外受精和胚胎移植中的功效和安全性分析" 24 (24): 3817-3818, 2020

8 Liu YJ, "健胎液对胚泡着床障碍小鼠雌, 孕激素及其受体的影响" 30 (30): 373-376, 2005

9 Gao Z, "二至增膜汤对IVF-ET 失败患者不良子宫内膜的应用研究" 32 (32): 2-3, 2013

10 Korean society of obstetrics and gynecology, "gynecology" Korean medical book 431-493, 2007

11 Cho JH, "Study on the effects of Samul-Tang for IVF in mice" 13 (13): 94-110, 2000

12 Sterne JAC, "RoB 2: a revised tool for assessing risk of bias in randomised trials" 366 : l4898-, 2019

13 Association of Busan Korean Medicine, "Reporting of oriental infertility treatment supporting program. 2015" Association of Busan Korean Medicine 2015

14 Association of Busan Korean Medicine, "Reporting of oriental infertility treatment supporting program. 2014" Association of Busan Korean Medicine 2014

15 Statistics Korea, "Population dynamics (live births and deaths) database" Statistics Korea

16 Park JY., "Oriental infertility treatment, there is no government support, while the number of local governments increases"

17 Kwon CY, "Oriental herbal medicine and moxibustion for polycystic ovary syndrome : a metaanalysis" 97 (97): e12942-, 2018

18 Lu G, "Moxibustion Ameliorates Ovarian Reserve in Rats by Mediating Nrf2/HO-1/NLRP3 Anti-Inflammatory Pathway" 2021 : 1-10, 2021

19 Dyer S, "International committee for monitoring assisted reproductive technology report : Assited reproductive technology 2008, 2009 and 2010" 31 (31): 1588-1609, 2016

20 Moon SY, "In vitro fertilization program" 50 (50): 431-439, 2007

21 Health Insurance Review and Assessment Service, "Health insurance payment schedule [Gŏngangbohŏm Yoyanggŭpyŏbiyong]" Aram Edit 2019

22 Sung YS, "Effects of Yuklinju on in vitro fertilization and embryo transfer" 12 (12): 161-184, 1999

23 Li H, "Effect of moxibustion on the red blood cell immune function and t cell subset of athletes" 33 (33): 415-418, 2015

24 Lee SJ, "Effect of Jokyong-Jongok-tang on the fertilization and maturation of immmature oocytes in bovine" 12 (12): 134-147, 1999

25 Gurunath S, "Defining infertility-a systematic review of prevalence studies" 17 (17): 575-588, 2011

26 Malizia BA, "Cumulative live-birth rates after In vitro Fertilization" 360 (360): 236-243, 2009

27 Li RX, "Comparison of traditional Chinese medicine and traditional Chinese medicine plus moxibustion for the treatment of primary dysmenorrhea(中药与中药加艾灸治疗原发性痛经疗效对照)" 19 (19): 4544-4545, 2010

28 Steen M, "Cold therapy and perineal wounds : too cool or not too cool" 6 (6): 572-579, 1998

29 Higgins JPT, "Cochrane Handbook for Systematic Reviews of Interventions version 6.3"

30 You XM, "Clinical study on warming-needle moxibustion for infertility patients with thin endometrium" 289 (289): 25-28, 2018

31 Li Y, "Clinical Study on the Influence for the Pregnancy Rate of Herb Cake-partitioned Moxibustion for the IVF-ET of Infertility Patients with Kidney Yang Deficiency" Yunnan College of Traditional Chinese Medicine 2018

32 Moon HJ, "Clinical Efficacy of Oriental Medicine in In Vitro Fertilization(IVF)" 14 (14): 127-135, 2001

33 Hwang N, "Analysis and evaluation of supporting project for infertility couples in 2016" Korea Institute for Health and Social Affairs 1-236, 2017

34 Koh YM, "A study on the effect of Yukmijihwangtang for IVF" 14 (14): 146-156, 2001

35 최수지 ; 박장경 ; 이미영 ; 김동일, "2017년도 경기도 한방 난임 지원 사업 진료 결과 분석 연구" 대한한방부인과학회 31 (31): 73-88, 2018