Non-pharmacological Approach in the Management of Functional Dyspepsia = Non-pharmacological Approach in the Management of Functional Dyspepsia

다국어 초록 (Multilingual Abstract)

Functional dyspepsia (FD) is a common functional gastrointestinal disease which bears a significant burden on society and individuals. Despite the high prevalence of FD, its pathophysiology remains poorly understood and the treatment options are limited and unsatisfactory. In the absence of effective pharmacological treatments for FD, non-pharmacological approaches, including: reassurance, lifestyle modification, psychotherapy, dietary interventions, medical food, acupuncture, and electrical stimulation and modulation are sought after by many physicians and FD patients. In this article, we review clinical studies which investigate non­pharmacological therapies for FD. We will also discuss potential mechanisms involved in the therapeutic effects of these non­pharmacological approaches. Though the evidences to support the routine use of the non-pharmacological management is still lacking, the non-invasive nature and potentially minimal side-effects of these therapies may be attractive in the FD management. In order to confirm the clinical effectiveness of these non-pharmacological approaches, more well-conducted, methodologically rigorous, and large-scaled clinical trials are required.

참고문헌 (Reference)

1 Madisch A, "Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride. A multicenter, reference-controlled double-blind equivalence study" 49 : 925-932, 1999

2 Van Oudenhove L, "The role of psychosocial factors and psychiatric disorders in functional dyspepsia" 10 : 158-167, 2013

3 Freedberg DE, "The risks and benefits of long-term use of proton pump inhibitors : expert review and best practice advice from the american gastroenterological association" 152 : 706-715, 2017

4 Enck P, "The placebo response in functional bowel disorders : perspectives and putative mechanisms" 17 : 325-331, 2005

5 Ciampa BP, "The emerging therapeutic role of medical foods for gastrointestinal disorders" 13 : 104-115, 2017

6 Dehghanizade Z, "The effectiveness of cognitive behavior stress management on functional dyspepsia symptoms" 3 : 45-49, 2015

7 Busch V, "The effect of transcutaneous vagus nerve stimulation on pain perception–an experimental study" 6 : 202-209, 2013

8 Ohtsu T, "The ameliorating effect of Lactobacillus gasseri OLL2716 on functional dyspepsia in Helicobacter pylori-uninfected individuals : a randomized controlled study" 96 : 92-102, 2017

9 Degnan FH, "The US food and drug administration and probiotics : regulatory categorization" 46 (46): S133-S136, 2008

10 Futagami S, "Systematic review with metaanalysis : post-infectious functional dyspepsia" 41 : 177-188, 2015

11 Mertz H, "Symptoms and visceral perception in severe functional and organic dyspepsia" 42 : 814-822, 1998

12 De la Roca-Chiapas JM, "Stress profile, coping style, anxiety, depression, and gastric emptying as predictors of functional dyspepsia : a case-control study" 68 : 73-81, 2010

13 Cao J, "Sa1116 significance of double steps reattribution integrative model for patients with functional dyspepsia(FD)" 144 : S205-S206, 2013

14 von Arnim U, "STW 5, a phytopharmacon for patients with functional dyspepsia : results of a multicenter, placebo-controlled double-blind study" 102 : 1268-1275, 2007

15 Malfertheiner P, "STW 5(Iberogast)therapy in gastrointestinal functional disorders" 35 (35): 25-29, 2017

16 Lacy BE, "Review article : current treatment options and management of functional dyspepsia" 36 : 3-15, 2012

17 Leelakusolvong S, "Response to marsden and ford" 111 : 1358-1359, 2016

18 Haug TT, "Psychotherapy in functional dyspepsia" 38 : 735-744, 1994

19 Hsu YC, "Psychopathology and personality trait in subgroups of functional dyspepsia based on Rome III criteria" 104 : 2534-2542, 2009

20 Quigley EMM, "Prokinetics in the management of functional gastrointestinal disorders" 19 : 53-, 2017

21 Lu CL, "Prevalence and health/social impacts of functional dyspepsia in Taiwan : a study based on the Rome criteria questionnaire survey assisted by endoscopic exclusion among a physical check-up population" 40 : 402-411, 2005

22 Talley NJ, "Predictors of the placebo response in functional dyspepsia" 23 : 923-936, 2006

23 Moayyedi P, "Pharmacological interventions for non-ulcer dyspepsia" CD001960-, 2006

24 Freise J, "Peppermint oil-caraway oil fixed combination in non-ulcer dyspepsia--comparison of the effects of enteric preparations" 54 : 210-215, 1999

25 Shams R, "Peppermint oil : clinical uses in the treatment of gastrointestinal diseases" 3 : 1035-1046, 2015

26 Göktaş Z, "Nutritional habits in functional dyspepsia and its subgroups : a comparative study" 51 : 903-907, 2016

27 Barbera R, "Nutrient-specific modulation of gastric mechanosensitivity in patients with functional dyspepsia" 40 : 1636-1641, 1995

28 Gathaiya N, "Novel associations with dyspepsia : a community-based study of familial aggregation, sleep dysfunction and somatization" 21 : 922-e969, 2009

29 Oshinsky ML, "Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia" 155 : 1037-1042, 2014

30 Talley NJ, "Non-ulcer dyspepsia and duodenal eosinophilia : an adult endoscopic population-based case-control study" 5 : 1175-1183, 2007

31 Gaul C, "Non-invasive vagus nerve stimulation for PREVention and acute treatment of chronic cluster headache(PREVA) : a randomised controlled study" 36 : 534-546, 2016

32 Kovacic K, "Neurostimulation for abdominal pain-related functional gastrointestinal disorders in adolescents : a randomised, double-blind, sham-controlled trial" 2 : 727-737, 2017

33 Melzer J, "Meta-analysis : phytotherapy of functional dyspepsia with the herbal drug preparation STW 5(Iberogast)" 20 : 1279-1287, 2004

34 Acker BW, "Medicinal foods for functional GI disorders" 19 : 62-, 2017

35 Langevin HM, "Manual and electrical needle stimulation in acupuncture research : pitfalls and challenges of heterogeneity" 21 : 113-128, 2015

36 Calvert EL, "Longterm improvement in functional dyspepsia using hypnotherapy" 123 : 1778-1785, 2002

37 Miwa H, "Life style in persons with functional gastrointestinal disorders--large-scale internet survey of lifestyle in Japan" 24 : 464-471, 2012

38 Sugano K, "Kyoto global consensus report on Helicobacter pylori gastritis" 64 : 1353-1367, 2015

39 Haag S, "Is there a benefit from intensified medical and psychological interventions in patients with functional dyspepsia not responding to conventional therapy?" 25 : 973-986, 2007

40 Xiao M, "Influence of hippophae rhamnoides on two appetite factors, gastric emptying and metabolic parameters, in children with functional dyspepsia" 16 : 38-43, 2013

41 Zeng F, "Influence of acupuncture treatment on cerebral activity in functional dyspepsia patients and its relationship with efficacy" 107 : 1236-1247, 2012

42 Gilja OH, "Impaired accommodation of proximal stomach to a meal in functional dyspepsia" 41 : 689-696, 1996

43 Sáez-González E, "Iberogast-induced severe hepatotoxicity leading to liver transplantation" 111 : 1364-1365, 2016

44 Santolaria Piedrafita S, "Gluten-sensitive enteropathy and functional dyspepsia" 35 : 78-88, 2012

45 Carbone F, "Gastroduodenal mechanisms underlying functional gastric disorders" 32 : 222-229, 2014

46 Stanghellini V, "Gastroduodenal disorders" 150 : 1380-1392, 2016

47 Nakae H, "Gastric microbiota in the functional dyspepsia patients treated with probiotic yogurt" 3 : e000109-, 2016

48 Holtmann G, "G-protein β3 subunit 825 CC genotype is associated with unexplained(functional)dyspepsia" 126 : 971-979, 2004

49 Drossman DA, "Functional gastrointestinal disorders : history, pathophysiology, clinical features and Rome IV" 150 : 1262-1279.e2, 2016

50 Tack J, "Functional gastroduodenal disorders" 130 : 1466-1479, 2006

51 Talley NJ, "Functional dyspepsia" 373 : 1853-1863, 2015

52 Duncanson KR, "Food and functional dyspepsia : a systematic review" 31 : 390-407, 2018

53 Cheng C, "Flexible coping psychotherapy for functional dyspeptic patients : a randomized, controlled trial" 69 : 81-88, 2007

54 Elli L, "Evidence for the presence of non-celiac gluten sensitivity in patients with functional gastrointestinal symptoms : results from a multicenter randomized double-blind placebo-controlled gluten challenge" 8 : 84-, 2016

55 Uday C Ghoshal, "Epidemiology of Uninvestigated and Functional Dyspepsia in Asia: Facts and Fiction" 대한소화기 기능성질환∙운동학회 17 (17): 235-244, 2011

56 Chen JDZ, "Electroacupuncture treatments for gut motility disorders" 30 : e13393-, 2018

57 Chey WD, "Efficacy of caraway oil/l-menthol plus usual care vs placebo plus usual care, in functional dyspepsia patients with post-prandial distress(PDS)or epigastric pain(EPS)syndromes : results from a US RCT" 152 : S307-, 2017

58 Kim KN, "Efficacy of acupuncture treatment for functional dyspepsia : a systematic review and meta-analysis" 23 : 759-766, 2015

59 May B, "Efficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsia" 46 : 1149-1153, 1996

60 May B, "Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia" 14 : 1671-1677, 2000

61 Zhou W, "Efficacy and safety of acupuncture for the treatment of functional dyspepsia : meta-analysis" 22 : 380-389, 2016

62 Beyazit Y, "Effects of transcutaneous electrical acustimulation in patients with functional dyspepsia" 31 : 1371-1372, 2010

63 Chiarioni G, "Complementary and alternative treatment in functional dyspepsia" 6 : 5-12, 2018

64 Köklü S, "Clinical trial : interferential electric stimulation in functional dyspepsia patients-a prospective randomized study" 31 : 961-968, 2010

65 Braden B, "Clinical effects of STW 5 (Iberogast) are not based on acceleration of gastric emptying in patients with functional dyspepsia and gastroparesis" 21 : 632-638, 2009

66 Aro P, "Anxiety is associated with uninvestigated and functional dyspepsia(Rome III criteria)in a Swedish population-based study" 13 : 94-100, 2009

67 Ji T, "An alternative to current therapies of functional dyspepsia : self-administrated transcutaneous electroacupuncture improves dyspeptic symptoms" 2014 : 832523-, 2014

68 Ford AC, "American college of gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation" 109 (109): S2-S26, 2014

69 Xu F, "Ameliorating effect of transcutaneous electroacupuncture on impaired gastric accommodation in patients with postprandial distress syndrome-predominant functional dyspepsia : a pilot study" 2015 : 168252-, 2015

70 Lan L, "Acupuncture for functional dyspepsia" CD008487-, 2014

71 Moayyedi P, "ACG and CAG clinical guideline : management of dyspepsia" 112 : 988-1013, 2017

72 Hamilton J, "A randomized controlled trial of psychotherapy in patients with chronic functional dyspepsia" 119 : 661-669, 2000

73 Faramarzi M, "A randomized controlled trial of brief psychoanalytic psychotherapy in patients with functional dyspepsia" 6 : 228-234, 2013

74 Orive M, "A randomized controlled trial of a 10 week group psychotherapeutic treatment added to standard medical treatment in patients with functional dyspepsia" 78 : 563-568, 2015

75 Rösch W, "A randomised clinical trial comparing the efficacy of a herbal preparation STW 5 with the prokinetic drug cisapride in patients with dysmotility type of functional dyspepsia" 40 : 401-408, 2002

76 Lee KJ, "A pilot study on duodenal acid exposure and its relationship to symptoms in functional dyspepsia with prominent nausea" 99 : 1765-1773, 2004