2019-2022년 국내에서 분리한 Erwinia amylovora균의 옥시테트라사이클린과 옥솔린산 항생제에 대한 저항성 평가 = Assessment of Oxytetracycline and Oxolinic acid Resistance of Erwinia amylovora Isolated from 2019 to 2022 in Korea

다국어 초록 (Multilingual Abstract)

Fire blight, a destructive plant disease causing great threats to the apple and pear industries, was first occurred in South Korea in 2015. Various pesticides have been registered and used for the control of fire blight.
Among them, antibiotics are known as very effective agents, but developed countries including Europe have been avoiding their use due to concerns about the emergence of antibiotic resistance and ecosystem disturbance.
Antibiotics have been used for fire blight control since 2015 in Korea, however, antibiotic resistance of the pathogen has not been systematically investigated yet. Therefore, in this study, we surveyed the minimal inhibition concentration (MIC) of Erwinia amylovora, a causal agent of fire blight, against the oxytetracycline and oxolinic acid using a total of 258 isolates that are collected from overall areas of South Korea from 2019 to 2022 to assess the presence of antibiotic resistance. The MIC of oxytetracycline was in a range of 0.25-2 µg/ml, and that of oxolinic acid was less than 0.25 µg/ml. In addition, the MIC of oxytetracycline was increased in 2022 compared to 2019. However, no significant differences in MIC existed between isolated regions or hosts. Taken together, the results indicate that oxytetracycline and oxolinic acid resistance may not occur in E. amylovora of Korea. This study also provides fundamental information to the assessment of resistance against antibiotics registered for the control of fire blight in Korea.