노인 환자에서의 신기능 추정 = Estimate the renal function of elderly patients

다국어 초록 (Multilingual Abstract)

It is important to estimate patient’s current renal function when renally-excreted drugs are administered to patients. Cockroft-Gault equation, which is used most commonly, predicts creatinine clearance by measuring the serum creatinine. Though it is far commonly used compared to other equations, it also has several limitations, resulting in toxic or inadequate events caused by overdosing or under-dosing. Especially, in elderly the renal toxicity should be monitored carefully. Sanaka equation has been proposed as a possible solution. With Sanaka equation, creatinine clearance can be estimated by measuring serum albumin in elderly patients with muscle atrophy. The objective of our study was to find out the correlation among Scr, body weight and albumin level in order to estimate the renal function of elderly patients accurately. From June 10 to August 9 2002, in Seoul National University Hospital, we performed the retrospective chart review on the non-ESRD patients with age over 60 and Ccr measured by 24hours urine collection. As a result, 152 patients(male: 93, female: 59) were included in the study. And their major diseases were diabetes (80) and cancer (59).
From the regression analysis, we obtained the following equations.
Female : CCr(ml/min) = [ - 24.6 + 12.7 (albumin) + 0.49 (ABW) ]/Scr
Male : CCr(ml/min) = [ - 26.3 + 12.9 (albumin) + 0.79 (ABW) ]/Scr
Further study is needed to compare our equation with Cockroft-Gault equation or Sanaka equation in the future.