Clinical Correlation between Gastric Cancer Type and Serum Selenium and Zinc Levels

다국어 초록 (Multilingual Abstract)

Purpose: We conducted this study to study the clinical correlation between the characteristics of gastric cancer and serum selenium and zinc levels.

Materials and Methods: The following data were measured in the baseline serum selenium and zinc levels of 74 patients with curative gastrectomy subsequent to confirmed gastric cancer, from March 2005 to August 2012.

Results: Among the 74 gastric cancer patients, 53 patients were male. Mean serum selenium and zinc levels were 118.7±33.1 ug/L and 72.2±24.3 ug/dl, respectively. Seven patients (9.5%) showed lower selenium level, and 33 patients (44.6%) showed lower zinc level. Serum Selenium level was 99.1±31.8 ug/L in cardia cancer group (10 cases) and 121.8±32.4 ug/L in non-cardia cancer group (64 cases)(P=0.044). According to tumor gross type, zinc level was 78.7±29.6 ug/dl in early gastric cancer (33) and 66.9±17.8 ug/dl in advanced gastric cancer (41) (P=0.064).

Conclusions: The serum selenium level was highly correlated with the location of gastric cancer. The serum zinc level was lower in advanced gastric cancer.

참고문헌 (Reference)

1 송승훈, "한국인에서 혈중 셀레늄(Selenium) 농도의 연령별 변화와 전립선암과의 상관관계" 대한비뇨기과학회 47 (47): 150-153, 2006

2 Atukorala S, "Vitamin A, zinc and lung cancer" 40 : 927-931, 1979

3 Longnecker MP, "Use of selenium concentration in whole blood, serum, toenails, or urine as a surrogate measure of selenium intake" 7 : 384-390, 1996

4 Birt DF, "Update on the effects of vitamins A, C, and E and selenium on carcinogenesis" 183 : 311-320, 1986

5 Navarro Silvera SA, "Trace elements and cancer risk: a review of the epidemiologic evidence" 18 : 7-27, 2007

6 Rayman MP, "The importance of selenium to human health" 356 : 233-241, 2000

7 Moghadaszadeh B, "Selenoproteins and their impact on human health through diverse physiological pathways" 21 : 307-315, 2006

8 Rotruck JT, "Selenium: biochemical role as a component of glutathione peroxidase" 179 : 588-590, 1973

9 Zeng H, "Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion" 19 : 1-7, 2008

10 Mark SD, "Prospective study of serum selenium levels and incident esophageal and gastric cancers" 92 : 1753-1763, 2000

11 Kabuto M, "Prediagnostic serum selenium and zinc levels and subsequent risk of lung and stomach cancer in Japan" 3 : 465-469, 1994

12 Biesalski HK, "Pocket Atlas of Nutrition. 3rd ed" Georg Thieme Verlag 2005

13 Fernandez-Madrid F, "Effect of zinc deficiency on nucleic acids, collagen, and noncollagenous protein of the connective tissue" 82 : 951-961, 1973

14 Morris JS, "Dietary selenium in humans toenails as an indicator" 5 : 529-537, 1983

15 Combs GF Jr, "Current evidence and research needs to support a health claim for selenium and cancer prevention" 135 : 343-347, 2005

16 Prasad AS, "Clinical, biochemical and nutritional spectrum of zinc deficiency in human subjects: an update" 41 : 197-208, 1983

17 Ip C, "Chemical form of selenium, critical metabolites, and cancer prevention" 51 : 595-600, 1991

18 Mclean AE, "Cellular permeability and the reaction to injury" 116 : 986-989, 1964

19 Fukuzawa K., "Biological defense systems in oxygen stress and new antioxidant drugs based on these systems, In Free Radicals in Clinical Medicine. Vol. 3" Nihon- Igakukan 1988

20 Rhee JK, "Association between cancer and selenium concentration in blood and toenails" 9 : 29-43, 1992

21 Shamberger RJ, "Antioxidants and cancer. Part VI. Selenium and age-adjusted human cancer mortality" 31 : 231-235, 1976