36-49岁北京地区女性皮肤皱纹与皮肤生理参数的关系 = Research on the Relationship between the Skin Biophysical Parameters versus Wrinkles of 36–49 Years Old Beijing Female

다국어 초록 (Multilingual Abstract)

Purpose: Skin biophysical parameters reveal skin condition of wrinkle. This study aimed to explore the variation of skin condition with wrinkles of 36–49 years old Beijing female. Methods: 55 healthy females (age ranged from 36 to 49 years old) coming from Beijing city were chosen for this study. We measured twenty one skin biophysical parameters such as skin hydration, transepidermal water loss (TEWL), sebum, melanin index (MI), erythema index (EI), skin shades, skin radiance, pH, transcutaneous oxygen tension (pO2), transcutaneous carbon dioxide tension (pCO2), skin temperature, blood perfusion, skin elasticity and skin texture in left cheek, and compared correlation between other parameters and elasticity and texture. Results: There were some correlations between skin biophysical parameters and skin elasticity and skin texture: (1) There were signifiant positive correlation (p<0.01) between skin elasticity parameters, R2, R5, R7, and skin radiance. Skin temperature was signifiantly (p<0.01) correlated with R5 positively. pO2 was signifiantly (p<0.01) correlated with R7 positively. There were negative correlation between three skin elasticity and pH. (2) There were signifiant positive correlation (p<0.01) between skin texture, Rz, and A. There were signifiant positive correlation (p<0.01) between two of skin texture, Ra, Rp, and EI. Conclusion: The correlations shown between the skin biophysical parameters and wrinkle factors demonstrate that the decrease of skin radiance, skin temperature and pO2, increase of skin pH, EI and skin shades A are affected by aging factors.

다국어 초록 (Multilingual Abstract)

目的: 皮肤生理参数能够揭示皮肤皱纹状况。本研究旨在探讨36–49岁北京女性皮肤各生理参数与皱纹之间的关系。 方 法: 选取北京市55名健康女性（年龄36–49岁）为研究对象，测定左脸颊二十一个皮肤生理参数如皮肤的水合作用、经 皮水分流失（transepidermal water loss, TEWL）、皮脂含量、黑色素指数（sebum, melanin index, MI）、红色素指数 （erythema index, EI）、皮肤颜色、皮肤光泽、pH值、经皮氧分压（transcutaneous oxygen tension, pO2）、经皮二氧 化碳分压（transcutaneous carbon dioxide tension, pCO2）、皮肤温度、血液灌流量、皮肤弹性及皮肤纹理，分析了各 皮肤生理参数与皮肤弹性、纹理的相关性关系。 结果: 皮肤各生理参数与皮肤弹性、皮肤纹理有一定相关性。（1）皮肤 弹性参数R2、R5、R7与和皮肤光泽度之间有显著的正相关（p<0.01）。皮肤温度与R5成显著正相关（p<0.01）。皮肤 pO2与R7成显著正相关（p<0.01）。皮肤弹性和pH值却呈负相关关系。（2） 皮肤纹理Rz和A之间存在显著的正相关关系 （p<0.01）。皮肤纹理Ra、Rp与和EI也具有显著正相关关系（p<0.01）。 结论: 各皮肤生理参数和皱纹之间的相关性表 明，年龄是影响皮肤光泽度，皮肤温度和氧分压的降低，皮肤pH，EI和皮肤颜色的上升的重要因素。

참고문헌 (Reference)

1 Hachem JP, "pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion" 121 : 345-353, 2003

2 Shi Y, "Wrinkles and skin photoaging" 32 : 156-158, 2006

3 Firooz A, "Variation of biophysical parameters of the skin with age, gender, and body region" 2012 : 386936-, 2012

4 Li Y, "Theory of relationship between "Yang Ming pulse failure" and the decline of reproductive axis function during menopause transition" 21 : 22-23, 2003

5 Trojahn C, "The skin barrier function: differences between intrinsic and extrinsic aging" 150 : 687-692, 2015

6 Choi EH, "Stratum corneum acidification is impaired in moderately aged human and murine skin" 127 : 2847-2856, 2007

7 Xu YM, "Research on the relationship between skin elasticity versus age and body-sites of female" 21 : 2266-2267, 2012

8 Jiao ZX, "Research on gloss evaluation of facial skin based on Retinex algorithm" 45 : 443-446, 2015

9 Zheng D, "Research on facial chromaticity dif ference between young and aged people" 13 : 275-281, 2011

10 Cui HL, "Relationship between skin color and age of people in the three regions of China" 27 : 204-207, 2013

11 Mu YD, "Relationship between maxillofacial complexion and age-sex in Han nationality" 11 : 32-34, 2005

12 Batrinos ML, "Premenopause : the endocrinology of reproductive decline" 12 : 334-349, 2013

13 Burger HG, "Perimenopause" Springer 170-183, 1997

14 Chauhan P, "Modeling signaling pathways leading to wrinkle formation : identification of the skin aging target" 75 : 463-468, 2009

15 Hang SS, "Human epidermal thickness and skin aging" 17 : 34-36, 2011

16 Zhang DS, "Huangdi nei jing" Tianjin Ancient Books Publishing House 3-, 2008

17 Wada Y, "Generic selection criteria for safety and patient benefit [IV] : physicochemical and pharmaceutical properties of brand-name and generic ketoprofen tapes" 9 : 229-233, 2015

18 Voet D, "Fundamentals of Biochemistry:life at the molecular level" Wiley 547-556, 2006

19 Thornton MJ, "Estrogens and aging skin" 5 : 264-270, 2013

20 Liao EY, "Endocrinology and metabolism" People's Medical Publishing House 51-, 2012

21 Kim EJ, "Effect of the regional environment on the skin properties and the early wrinkles in young Chinese women" 20 : 498-502, 2014

22 Mima Y, "Different effects of diabetic autonomic neuropathy on regional transcutaneous oxygen tension in patients with peripheral arterial disease" 56 : 27-36, 2010

23 Shao L, "Collection and analysis of maxillofacial skin chromatic value of the residents in Xi 'an area" 15 : 274-276, 1999

24 Valdes-Rodriguez R, "Chronic pruritus in the elderly : pathophysiology, diagnosis and management" 32 : 201-215, 2015

25 Hansen KR, "A new model of reproductive aging : the decline in ovarian non-growing follicle number from birth to menopause" 23 : 699-708, 2008