Brain Factor-7 Extracted from Bombyx mori Enhances Cognition and Attention in Normal Children

다국어 초록 (Multilingual Abstract)

It has been reported that brain factor-7 (BF-7) extracted from Bombyx mori improves cognitive functions in normal juveniles and adults as well as cognitively impaired patients. Clinical studies with normal children evaluated the role of BF-7 on brain function in these patients. The objective of this study was to improve cognitive functions of normal schoolchildren with BF-7. Forty-six normal healthy children were divided into two treatment groups: BF-7 (9.9±1.18 years old; 9 boys, 14 girls) and placebo (9.8±1.03 years old; 10 boys, 13 girls). The Color Trails Making Test was used to measure the efficacy of BF-7 on cognition and attention. Results showed that BF-7 reduced the response time by an average of 23% for the Color Trails Making Test. Moreover, BF-7 improved the accuracy of the task around twofold. The results reveal that BF-7 improves brain function for attention and cognitive flexibility in children.

참고문헌 (Reference)

1 Stuss DT, "Wisconsin Card Sorting Test performance in patients with focal frontal and posterior brain damage: effects of lesion location and test structure on separable cognitive processes" 38 : 388-402, 2000

2 Stone WL, "The social status of children with learning disabilities: a reexamination" 23 : 23-37, 1990

3 Kim DK, "The role of BF-7 on enhancement of memory and cognitive function" 37 : 519-527, 2004

4 채희선, "The role of BF-7 on Neuroprotection and Enhancement of Cognitive Function" 대한약리학회 8 (8): 173-180, 2004

5 Wright-Strawderman C, "The prevalence of depression symptoms in children with learning disabilities" 25 : 58-264, 1992

6 Nathan PJ, "The neuropharmacology of l-theanine (Nethyl-l-glutamine): a possible neuroprotective and cognitive enhancing agent" 6 (6): 21-30, 2006

7 Hu JD, "The improvement of taurine in learning and memory ability of rats exposed to lead" 21 : 413-416, 2003

8 Lee JY, "The effect of BF-7 on the ischemia-induced learning and memory deficits" 38 : 181-188, 2005

9 김영신, "The Reliability and Validity of Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version-Korean Version (K-SADS-PL-K)" 연세대학교의과대학 45 (45): 81-89, 2004

10 이상형, "The Improvement of Learning and Memory Ability of Normal Persons by BF-7" 대한약리학회 8 (8): 307-312, 2004

11 Gresham FM, "Social skills deficits as a primary learning disability" 22 : 120-124, 1989

12 Bundra A, "Self-efficacy: toward unifying theory of behavioral change" 84 : 191-215, 1977

13 Kaufman J, "Schedule for Affective Disorders and Schizophrenia for School-Age Children—Present and Lifetime Version (K-SADS-PL): initial reliability and validity data" 39 : 980-988, 1997

14 Orvaschel H, "Retrospective assessment of prepubertal major depression with the Kiddie-SADS-e" 21 : 392-397, 1982

15 Kakuda T, "Protective effect of gamma-glutamylethylamide (theanine) on ischemic delayed neuronal death in gerbils" 289 : 189-192, 2000

16 Dove A, "Prefrontal cortex activation in task switching: an event-related fMRI study" 9 : 103-109, 2000

17 Vetulani J, "Nimodipine on shuttle-box avoidance learning in mice: no impairment but slight improvement" 56 : 577-581, 1997

18 Kim DK, "Neuroprotection and enhancement of learning and memory by BF-7" 51 : 317-324, 2005

19 Ozer EM, "Mechanism governing empowerment effects: a self-efficacy analysis" 58 : 472-486, 1990

20 Cermak LS, "Improving Your Memory" McGraw-Hill 1976

21 He R, "Improvement of learning and memory functions by rice flavoids in mice" 25 : 108-111, 2002

22 Onodera K, "Improvement by FUB 181, a novelhistamine H3-receptor antagonist, of learning and memory in the elevated plus-maze test in mice" 357 : 508-513, 1998

23 Mitrushina MN, "Handbook of Normative Data for Neuropsychological Assessment" Oxford University Press 1999

24 Jaffard R, "Effects of tianeptine on learning and memory in mice. Improvement of impairments induced by chronic alcoholism and brain aging" 20 : 1812-1816, 1991

25 Schunk DH, "Effects of effort attribution feedback on children’sperceived self-efficacy and achievement" 74 : 548-556, 1982

26 Ozaki S, "Effect of bifemelane hydrochloride in rats on the improvement of the learning and memory impairments and prevention of neuronal damage following transient forebrain ischemia" 104 : 469-480, 1994

27 "Diagnostic and Statistical Manual of Mental Disorders, 4th ed" American Psychiatric Association 1994

28 Konishi S, "Contribution of working memory to transient activation in human inferior prefrontal cortex during performance of the Wisconsin Card Sorting Test" 9 : 745-753, 1999

29 Spreen O, "Comparative studies of some psychological tests for cerebral damage" 140 : 323-333, 1965

30 D’Elia LF, "Color Trails Test: Professional Manual" Psychological Assessment Resources 1996

31 Yeo JH, "Cognitive ability enhancement effects in rats by B. mori fibroin by enzymatic hydrolysate" 46 : 23-27, 2004

32 이무열, "BF-7의 기억력 향상효과 및 산화적 스트레스로 인한 신경손상의 억제효과" 대한체질인류학회 17 (17): 313-320, 2004

33 Lee SH, "Association between cerebral blood flow and cognitive improvement effect by B. mori extracted component" 46 : 77-79, 2004

34 "American Heritage Dictionary" Houghton Mifflin Co 1971

35 Frederiksen CH, "Acquisition of semantic information from discourse: effects of repeated exposures" 4 : 158-169, 1975

36 Kunen SCRK, "A levels of processing analysis of Bloom’s taxonomy" 73 : 202-211, 1981