진균의 단백질분해효소에 의한 비강 상피세포의 활성화 = Protease from Airborn Fungi Induce Activation of Nasal Epithelial Cells

다국어 초록 (Multilingual Abstract)

Background and Objectives：The nasal epithelium is the first barrier encountered by airborne allergens and an active participant in airway inflamation. Fungi have ben increasingly recognized as important pathogens in sinusitis and consists of several sm of epithelial cell activation. Subjects and Method：The epithelial cels of nasal polyp were obtained from patients and stimulated with Alternaria, Aspergillus, and Cladosporium. Interleukin-8 (IL-8), granulocyte-macrophage colony stimulating factor (GM-CSF), regulated on activation and normal T expressed and secreted (RANTES) were measured to determine the activation of tase-polymerase chain reaction (RT-PCR) test for protease-activated receptors (PARs) mRNA expresion in nasal epithelial cells were performed. Results：Fungi enhanced the production of chemical mediators from nasal epithelial cels. Serine protease inhibitors inhibited the activation of nasal epithelial cells. When nasal epithelial cells were activated, PAR2 and PAR3 mRNAs were more strongly expresed than non-activated cells. Conclusion：enhance the production of inflamatory cytokines. PARs might play a role in the proces of epithelial cell activation.

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