성인 뇌손상 환자에서 혈청 및 뇌척수액 IL-6 치의 변화

다국어 초록 (Multilingual Abstract)

Cytokines may have involved in the pathophysiology of traumatic brain injury(TBI) in adults. Interleukine-6(IL-6) plays a major role in initiating the acute phase response, especially in the production of acute phase reactants. The objective of this study was to determine whether serum IL-6 and cerebrospinal fluid(CSF) IL-6 levels were elevated at the time of admission after head injury and to correlate serum IL-6 and CSF IL-6 levels wi th severity of head injury measured by the Glasgow Coma Scale(GCS) score and intracranial pressure(ICP). Twenty one patients with GCS score between 4 and 14(mean=9) were observed for 3-5 days after head injury. The highest level of serum IL-6 was found on admission day 1(8.2±4.9 pg/ml; normal level is less than 0.4 pg/ml±O.2pg/ml) and then it decreased to 4.O±3.6pg/ml on day 5. Serum IL-6 levels decreased significantly faster in patients with 24-hour GCS scores of 8 through 11 compared with patients wi th 24 hour GCS score＜8. Patients had markedly elevated CSF IL-6 levels on admission compared with controls(46.6±4.2pg/ml vs ＜20.6±5.8pg/ml). This studies indicated that patients with severe head injury had markedly elevated serum and CSF IL-6 levels wi thin 24 hours of head injury. which decreased over time. Serum IL-6 levels were significantly more elevated in the patients with low GCS and increased ICP. This study demonstrates that serum and CSF IL-6 levIes correlate with severity of traumatic brain injury and warrants further evaluation to determine the exact role of IL-6 in injury repair in the brain.

국문 초록 (Abstract)

본 연구에서는 성인 외상성 뇌손상 환자 혈청 및 뇌 척수액의 IL-6 수치가 뇌손상 초기에 정상보다 증가되어 있었고 시간의 경과에 따라 감소하였다. 의식수준이 낮을수록 혈청의 IL-6가 높게 나타났으며 뇌척수액의 IL-6는 혈청의 IL-6보다 의미있는 증가를 보였다. 그리고 두개강 내압이 높을 수록 IL-6는 더욱 증가를 보였다. 또한 IL-6의 수치는 임상적 호전의 정도에 따라 감소함을 보였다. 이 사실은 IL-6가 뇌손상을 받은 환자의 급성기 반응에서 매개체로 중요한 역할을 한다는 사실을 시사해 주고 있다. 뇌손상 환자에서 IL-6의 구체적 역할을 규명하기 위하여는 추후 지속적인 연구가 필요할 것으로 사료된다.

목차 (Table of Contents)

• 目次 = 0
• Ⅰ. 서론 = 1
• Ⅱ. 대상 및 방법 = 3
• Ⅲ. 결과 = 6
• Ⅳ. 고찰 = 14
• Ⅴ. 요약 = 18
• Ⅵ. 참고문헌 = 19
• =Abstract= = 26