Medicinal potential of Panax ginseng and its ginsenosides in atopic dermatitis treatment

다국어 초록 (Multilingual Abstract)

Atopic dermatitis (AD) is a chronic and relapsing inflammatory disease that affects 1%e20% of peopleworldwide. Despite affecting many people, AD current treatments, such as corticosteroids and calcineurininhibitors, have not only harmful secondary effects but are also often ineffective. Therefore,natural nontoxic compounds are on high demand for developing new effective AD treatments. Panaxginseng Meyer has been used traditionally for its promising healing and restorative properties to treatmany diseases including skin disorders, reason why in this review we want to explore the researchperformed with AD and P. ginseng as well as determining its potential for new drug development.
Previous researches have shown that P. ginseng has positive effects in AD patients such as lower eczemaarea and severity index, transepidermal water loss, and immunoglobulin E levels and better quality ofsleep. In vivo animal models, as well, have shown positive results to P. ginseng and derived ginsenosides,such as the decrease of transepidermal water loss, immunoglobulin E levels in serum, allergy-relatedcytokines, and downregulation of NF-kB, MAPK, and Ikaros pathways. All of these previous datasuggest that P. ginseng and its derived ginsenosides are undoubtedly a nontoxic effective option to treatAD.

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