육두구(Myristica fragrans Houtt)로부터 Phenylpropanoid의 분리 = Phenylpropanoids from Myristica fragrans Houtt

다국어 초록 (Multilingual Abstract)

Myristica fragrans Houtt were extracted in 80% aq. MeOH and solvent fractionated using CHCl3, EtOAc,
n-BuOH and water, successively. The n-BuOH fraction gave three phenylpropanoids through application of silica gel
column chromatographies. The chemical structures of the phenylpropanoids were determined by the interpretation of
several spectral data, including NMR and MS as meso-dihydroguaiaretic acid (1), nectandrin B (2) and syringin
methyl ether (3). Compound 1, which was first isolated from this plant by authors, showed inhibitory activities with
60.02.1% (100 μg/ml), 42.60.9% (140 μg/ml) and 12.20.2% (200 μg/ml) on ACAT(acyl-CoA:Cholesterol
Acyltransferase), chitin synthase III and HMG-CoA reductase (3-hydroxy-3-methylglutaryl coenzyme A reductase),
respectively. Compound 3 showed inhibitory activities with 27.20.9% (100 μg/ml), 45.50.8% (200 μg/ml) on
ACAT and chitin synthase III.

참고문헌 (Reference)

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