Thematic Poster : TP-20 ; Lung Function Impairment According to Prior Pulmonary Tuberculosis = Thematic Poster : TP-20 ; Lung Function Impairment According to Prior Pulmonary Tuberculosis

다국어 초록 (Multilingual Abstract)

Background: Previous pulmonary tuberculosis (TB) can affect lung function, but a few data exist on long-term follow-up. This study was conducted to evaluate whether prior pulmonary TB was related with lung function impairment in Korean adult population and risk factors of decreased lung function in subjects with prior pulmonary TB. Methods: We used data from the fourth and fifth annual South Korean National Health and Nutrition Examination Survey (Korean NHANES IV) conducted in 2008, 2009, 2010, 2011 and 2012. From a total of 45,811 subjects, 14,967 adult subjects who were at least 40 years of age were included in the study population. The correlation between prior pulmonary TB and chest x-ray abnormality and impaired lung function using questionnaires about diagnosis of pulmonary tuberculosis, chest x-ray and pulmonary lung function were analyzed. The results of pulmonary functions were all adjusted by age, sex and smoking pack-years. Results: Mean age was 57.1years and males were 43.3%. Subjects with preciously diagnosed and treated pulmonary TB were 5.5%. Chest PA with sequale of pulmonary tuberculosis was 7.9%. FEV1%, FEV1/FVC in subjects with prior pulmonary TB were significantly low compared with those without TB (84.89±17.19 vs. 92.58±13.51, P＜0.001, and 77.91±7.52 vs. 77.91±7.52, P＜0.001, respectively). Subjects with prior pulmonary TB had higher prevalence of COPD compared with those without previous TB (19.5% vs. 6.5%, OR=2.862, 95% CI: 2.344-3.496), also in subjects with normal chest x-ray (9.1% vs. 5.0%, OR=1.702, 95% CI: 1.112-2.607). In subject with prior pulmonary TB, TB sequale on chest x-ray was risk factor of COPD development (OR=2.244, 95% CI: 1.578-3.191). Conclusion: In the current study, previous pulmonary TB morbidity was significantly related with decreased lung function in Korean adults. The evaluation and follow up of pulmonary function in subjects with previous pulmonary TB should be needed.