Cytotoxic Constituents from the Whole Plant of Corydalis pallida

다국어 초록 (Multilingual Abstract)

Here we report the cytotoxic activity of three known compounds isolated for the first time from Corydalis pallida (Papaveraceae). An isoquinoline alkaloid, berberine, exhibited cytototoxic activity against two human cancer cell lines, HT-1080 (human fibrosarcoma) and SNU-638 (human stomach adenocarcinoma), with IC50 values of 3.2 and 3.4 µg/mL, respectively. Ntrans- feruloyltyramine and N-trans- feruloylmethoxytyramine were also isolated from this plant but were inactive.

참고문헌 (Reference)

1 "effects on seeds germination and plantgrowth. Phytochemistry" 64 : 1381-1387, 2003

2 "Useof ferulic acid amides as flavoring materials for foods and oralhygiene products. Eur. Pat. Appl." 12 : 2003

3 "The alkaloids of fumariaceous plants. XXV.Corydalis pallida Pers. Can. J. Res." 80-83, 1940

4 "Scavenging effect ofberbamine on active oxygen radicals in phorbol esterstimulatedhuman polymorphonuclear leukocytes. Biochem.Pharmacol." 1673-1678, 1990

5 "Examination of thenitric oxide production-suppressing component in Tinosporatuberculata. Biol. Pharm. Bull." 24 : 1153-1156, 2001

6 "Effects of Liandai tablet and its main active components ongastric cancer cell line MGC-803. Guangzhou ZhongyiyaoDaxue Xuebao" 18 : 67-70, 2001

7 "Cytotoxicity of reaction-precipitate from Coptidis Rhizomaand Glycyrrhizae Radix aqueous mixture. SaengyakHakhoechi" 356-62, 1994

8 "Cytostatic mechanism and antitumor potential of novel1H-cyclopenta[b]benzofuran lignans isolated form Aglaiaelliptica. Chemico-Biological Interac." 115 : 215-228, 1998

9 "Constituents of Corydalis species.VII. Constituents of Corydalis pallida var. tenuis. YakugakuZasshi." 101-108, 1971

10 "Comparative effects of tetrandrine and berbamine onsubcutaneous air pouch inflammation induced by interleukin-1" 112-118, 1992

11 "Chemopreventive activity of isoquinolinealkaloids from Corydalis plants. Planta Med." 67 : 473-475, 2001

12 "Carbon-13 NMR assignments of berberineand sanguinarine. Heterocycles" 911-16, 1988

13 "Berberine alkaloids as a treatment for chronic" 17 : 1998

14 "Antioxidants from plants for therapeutic uses. Jpn. KokaiTokkyo Koho" 6 : 2000

15 "Antioxidant and lipophilic constituents of Tinospora crispa.Planta Med." 64 : 393-396, 1998

16 "Antimicrobial properties of berberine andpossibilities of its use in therapy. Herba Polonica" and (and): 105-112, 1992

17 "Amidesfrom stems of Annona cherimola. Phytochemistry" 49 : 1443-1447, 1998

18 "Alkaloids from Callus tissueof Papaver somniferum. Phytochemistry" and syo : 3041-3044, 1972

19 "Activation ofperitoneal macrophages by berberine-type alkaloids in termsof induction of cytostatic activity. Int. J. Immunopharmacol." 587-592, 1984

20 "A phenolicamide from Actinodaphne longifolia. Phytochemistry" ichi : 2516-2517, 1989