스테로이드 치료 전 DHEA 단독투여와 DHEA 투여와 운동의 동시적용이 스테로이드에 의해 유발되는 쥐 뒷다리근의 위축 예방에 미치는 효과 = Effect of DHEA Administration Alone or Exercise combined with DHEA before Steroid Treatment on Rat Hindlimb Muscles

다국어 초록 (Multilingual Abstract)

Purpose: The purpose of this study was to determine the effect of Dehydroepiandrosterone (DHEA) administration alone
or exercise combined with DHEA before steroid treatment on rat hindlimb muscles. Methods: Male Sprague-Dawley rats
were assigned to one of three groups: a steroid group (S, n=10) that had no treatment for 7 days before steroid treatment;
a DHEA-steroid group (DS, n=8) that had 0.34 mmol/kg/day DHEA injection once a day for 7 days before steroid treatment
and an exercise+DHEA-steroid group (EDS, n=9) that ran on the treadmill combined with 0.34 mmol/kg/day DHEA
injection for 7 days before steroid treatment. At 15 days all rats were anesthetized and soleus, plantaris and gastrocnemius
muscles were dissected. Body weight, food intake, muscle weight, myofibillar protein content and cross-sectional
area of the dissected muscles were determined. Results: The DS group showed significant increases (p<.05) as compared
to the steroid group in body weight, and muscle weight of gastrocnemius muscles. The EDS group showed significant
increases (p<.05) as compared to the S group in body weight, muscle weight, myofibrillar protein content, and Type II
fiber cross-sectional area of soleus, plantaris and gastrocnemius muscles. Conclusion: Exercise combined with DHEA
administration before steroid treatment prevents steroid induced muscle atrophy, with exercise combined with DHEA
administration being more effective than DHEA administration alone in preventing muscle atrophy.

다국어 초록 (Multilingual Abstract)

Purpose: The purpose of this study was to determine the effect of Dehydroepiandrosterone (DHEA) administration alone
or exercise combined with DHEA before steroid treatment on rat hindlimb muscles. Methods: Male Sprague-Dawley rats
were assigned to one of three groups: a steroid group (S, n=10) that had no treatment for 7 days before steroid treatment;
a DHEA-steroid group (DS, n=8) that had 0.34 mmol/kg/day DHEA injection once a day for 7 days before steroid treatment
and an exercise+DHEA-steroid group (EDS, n=9) that ran on the treadmill combined with 0.34 mmol/kg/day DHEA
injection for 7 days before steroid treatment. At 15 days all rats were anesthetized and soleus, plantaris and gastrocnemius
muscles were dissected. Body weight, food intake, muscle weight, myofibillar protein content and cross-sectional
area of the dissected muscles were determined. Results: The DS group showed significant increases (p<.05) as compared
to the steroid group in body weight, and muscle weight of gastrocnemius muscles. The EDS group showed significant
increases (p<.05) as compared to the S group in body weight, muscle weight, myofibrillar protein content, and Type II
fiber cross-sectional area of soleus, plantaris and gastrocnemius muscles. Conclusion: Exercise combined with DHEA
administration before steroid treatment prevents steroid induced muscle atrophy, with exercise combined with DHEA
administration being more effective than DHEA administration alone in preventing muscle atrophy.

참고문헌 (Reference)

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