蛋白食餌條件을 달리하여 成長한 흰쥐에 四鹽化炭素 投與가 Purine體 代謝酵素活性에 미치는 영향 = EFFECT OF CARBON TETRCHLORIDE ADMINISTRATION ON THE ACTIVITIES OF PURINE CATABOLIZING ENZYMES IN RATS FED A LOW OR STANDARD PROTEIN DIET

다국어 초록 (Multilingual Abstract)

The effect of CCl_4 injection on the activities of some purine catabolizing enzymes, the levels of serum uric acid and allantoin was studied on male rats previously fed a low protein-high-carbohydrate(7% casein) of a standard protein-low carbohydrate(20% casein).
The increasing rate of serum uric acid and allantoin to the control group by the injection of CCl_4 was higher in rats fed a standard protein diet than those fed a low protein diet.
The hepatic levels of purine catabolizing enzyme activities; adenosine deaminase(ADA), guanase(GDA), xanthine oxidase(XOD) and uricase in rats fed a low protein diet, were more decreased than those fed a standard protein diet. An increasing rate of the sum activity in serum and liver of each purine catabolizing enzyme, i.e, ADA, GDA, XOD, to each control group was higher in CCl_4-treated rats fed a standard protein diet than those fed a low protein diet.
The decreasing rate of XOD activity in CCl_4-treated rats pretreated with actinomycin D to the CCl_4-treatd group was higher in rats fed a standard protein diet than in those fed a low protein diet. Furthermore, injection of actinomycin D to the rats fed a standard protein diet showed a significantly decreased activity of hepatic XOD, compared with its control group, but injection of actinomycin D to the rats fed a low protein diet showed the similar level of enzyme activity with its control group. And the decreasing rate of liver XOD to the CCl_4-treated rats in actinomycin D pretreated-rats was lower in rats fed a low protein diet than in those fed a standard protein diet