<P>Intermittent fasting (IF), a periodic energy restriction, has been shown to provide health benefits equivalent to prolonged fasting or caloric restriction. However, our understanding of the underlying mechanisms of IF-mediated metabolic benef...
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https://www.riss.kr/link?id=A107428713
Kim, Kyoung-Han ; Kim, Yun Hye ; Son, Joe Eun ; Lee, Ju Hee ; Kim, Sarah ; Choe, Min Seon ; Moon, Joon Ho ; Zhong, Jian ; Fu, Kiya ; Lenglin, Florine ; Yoo, Jeong-Ah ; Bilan, Philip J ; Klip, Amira ; Nagy, Andras ; Kim, Jae-Ryong ; Park, Jin Gyoon ; Hussein, Samer MI ; Doh, Kyung-Oh ; Hui, Chi-chung ; Sung, Hoon-Ki
2017
-
SCOPUS,SCIE
학술저널
1309-1326(18쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>Intermittent fasting (IF), a periodic energy restriction, has been shown to provide health benefits equivalent to prolonged fasting or caloric restriction. However, our understanding of the underlying mechanisms of IF-mediated metabolic benef...
<P>Intermittent fasting (IF), a periodic energy restriction, has been shown to provide health benefits equivalent to prolonged fasting or caloric restriction. However, our understanding of the underlying mechanisms of IF-mediated metabolic benefits is limited. Here we show that isocaloric IF improves metabolic homeostasis against diet-induced obesity and metabolic dysfunction primarily through adipose thermogenesis in mice. IF-induced metabolic benefits require fasting-mediated increases of vascular endothelial growth factor (VEGF) expression in white adipose tissue (WAT). Furthermore, periodic adipose-VEGF overexpression could recapitulate the metabolic improvement of IF in non-fasted animals. Importantly, fasting and adipose-VEGF induce alternative activation of adipose macrophage, which is critical for thermogenesis. Human adipose gene analysis further revealed a positive correlation of adipose VEGF-M2 macrophage-WAT browning axis. The present study uncovers the molecular mechanism of IF-mediated metabolic benefit and suggests that isocaloric IF can be a preventive and therapeutic approach against obesity and metabolic disorders.</P>