감국에서 분리한 Kikkanol F Monoacetate와 5-Hydroxy-6,7,3',4'- tetramethoxyflavone의 IL-6 생성억제활성 = Effect of Kikkanol F Monoacetate and 5-Hydroxy-6,7,3',4'- tetramethoxyflavone Isolated from Chrysanthemum indicum L. on IL-6 Production

다국어 초록 (Multilingual Abstract)

Searching for inhibitors of lipopolysaccharide (LPS)-induced IL-6 (Interleukin-6) production from medicinal herbs, we isolated two active compounds through bioactivity-guided fractionation from the methanol extract of Chrysanthemum indicum L.. They were determined as kikkanol F monoacetate (1) and 5-hydroxy-6, 7, 3', 4'-tetramethoxyflavone (2) by means of spectroscopy techniques such as NMR and MS. The compound 1 and 2 inhibited LPS-induced IL-6 production in the RAW264.7 cells with IC50 value of 47 µg/ml and 27 µg/ml, respectively.

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