Small Malignant Hepatic Tumor Detection in Gadolinium- and Ferucarbotran-Enhanced Magnetic Resonance Imaging: does Combining Ferucarbotran-Enhanced T2*-Weighted Gradient Echo and T2-Weighted Turbo Spin Echo Images have Additive Efficacy?

다국어 초록 (Multilingual Abstract)

Objective: To determine if a combination of ferucarbotran-enhanced
T2*weighted-gradient echo (T2*W-GRE) and T2-weighted turbo spin echo (T2WTSE) images in gadolinium- and ferucarbotran-enhanced MRI has additive efficacy compared to each image alone for detecting small (≤ 2.0 cm) hepatocellular carcinoma (HCC) lesions in a group of cirrhotic patients and metastases in a group of non-cirrhotic patients.
Materials and Methods: Two readers retrospectively analyzed gadoliniumand
ferucarbotran-enhanced T2*W-GRE, T2W-TSE, and combined T2*WGRE/
T2W-TSE images of 119 patients with 157 HCCs and 32 patients with 98
metastases. The diagnostic accuracy and sensitivity for each image set and the combined set were evaluated using the alternative-free response receiver operating characteristic method.
Results: The mean area under the curve value of the combined set (0.966)
tended to be better than that for each individual image set (T2W-TSE [0.910],
T2*W-GRE [0.892]). Sensitivities in the combined set were higher than those in each individual image set for detecting HCC (mean, 93.0% versus 81.6% and 86.7%, respectively, p < 0.01). Sensitivities in the combined set and the T2WTSE set were the same for detecting metastases, and both were higher than the sensitivity seen in the T2*W-GRE set (mean, 97.5% versus 85.2 %, p < 0.01).
Conclusion: Combining ferucarbotran-enhanced T2*W-GRE and T2W-TSE
has additive efficacy for detecting HCC in cirrhotic patients, but T2W-TSE is preferred for detecting metastases in non-cirrhotic patients.

다국어 초록 (Multilingual Abstract)

Objective: To determine if a combination of ferucarbotran-enhanced
T2*weighted-gradient echo (T2*W-GRE) and T2-weighted turbo spin echo (T2WTSE) images in gadolinium- and ferucarbotran-enhanced MRI has additive efficacy compared to each image alone for detecting small (≤ 2.0 cm) hepatocellular carcinoma (HCC) lesions in a group of cirrhotic patients and metastases in a group of non-cirrhotic patients.
Materials and Methods: Two readers retrospectively analyzed gadoliniumand
ferucarbotran-enhanced T2*W-GRE, T2W-TSE, and combined T2*WGRE/
T2W-TSE images of 119 patients with 157 HCCs and 32 patients with 98
metastases. The diagnostic accuracy and sensitivity for each image set and the combined set were evaluated using the alternative-free response receiver operating characteristic method.
Results: The mean area under the curve value of the combined set (0.966)
tended to be better than that for each individual image set (T2W-TSE [0.910],
T2*W-GRE [0.892]). Sensitivities in the combined set were higher than those in each individual image set for detecting HCC (mean, 93.0% versus 81.6% and 86.7%, respectively, p < 0.01). Sensitivities in the combined set and the T2WTSE set were the same for detecting metastases, and both were higher than the sensitivity seen in the T2*W-GRE set (mean, 97.5% versus 85.2 %, p < 0.01).
Conclusion: Combining ferucarbotran-enhanced T2*W-GRE and T2W-TSE
has additive efficacy for detecting HCC in cirrhotic patients, but T2W-TSE is preferred for detecting metastases in non-cirrhotic patients.

참고문헌 (Reference)

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