Tie2 is tied at the cell-cell contacts and to extracellular matrix by Angiopoietin-1

다국어 초록 (Multilingual Abstract)

Angiopoietin-1 (Ang1) binds to and activates Tie2 receptor
tyrosine kinase. Ang1-Tie2 signal has been proposed
to exhibit two opposite roles in the controlling
blood vessels. One is vascular stabilization and the
other is vascular angiogenesis. There has been no answer
to the question as to how Tie2 induces two opposite
responses to the same ligand. Our group and Dr.
Alitalo’s group have demonstrated that trans-associated
Tie2 at cell-cell contacts and extracellular matrix
(ECM)-anchored Tie2 play distinct roles in the endothelial
cells. The complex formation depends on the presence
or absence of cell-cell adhesion. Here, we review
how Ang1-Tie2 signal regulates vascular maintenance
and angiogenesis. We further point to the unanswered
questions that must be clarified to extend our knowledge
of vascular biology and to progress basic knowledge
to the treatment of the diseases in which
Ang1-Tie2-mediated signal is central.

다국어 초록 (Multilingual Abstract)

Angiopoietin-1 (Ang1) binds to and activates Tie2 receptor
tyrosine kinase. Ang1-Tie2 signal has been proposed
to exhibit two opposite roles in the controlling
blood vessels. One is vascular stabilization and the
other is vascular angiogenesis. There has been no answer
to the question as to how Tie2 induces two opposite
responses to the same ligand. Our group and Dr.
Alitalo’s group have demonstrated that trans-associated
Tie2 at cell-cell contacts and extracellular matrix
(ECM)-anchored Tie2 play distinct roles in the endothelial
cells. The complex formation depends on the presence
or absence of cell-cell adhesion. Here, we review
how Ang1-Tie2 signal regulates vascular maintenance
and angiogenesis. We further point to the unanswered
questions that must be clarified to extend our knowledge
of vascular biology and to progress basic knowledge
to the treatment of the diseases in which
Ang1-Tie2-mediated signal is central.

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