<P><B>Abstract</B></P> <P>Kakeromamide A (<B>1</B>), a new cyclic pentapeptide encompassing a thiazole ring moiety and a <I>β</I>-amino acid, was isolated from the marine cyanobacterium <I...
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https://www.riss.kr/link?id=A107725537
2018
-
학술저널
2206-2209(4쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P><B>Abstract</B></P> <P>Kakeromamide A (<B>1</B>), a new cyclic pentapeptide encompassing a thiazole ring moiety and a <I>β</I>-amino acid, was isolated from the marine cyanobacterium <I...
<P><B>Abstract</B></P> <P>Kakeromamide A (<B>1</B>), a new cyclic pentapeptide encompassing a thiazole ring moiety and a <I>β</I>-amino acid, was isolated from the marine cyanobacterium <I>Moorea bouillonii</I>. Its structure was elucidated by the spectral analysis and the modified Marfey’s method. Compound <B>1</B> induced differentiation of neural stem cells into astrocytes at the concentration of 10 µM.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new cyclic pentapeptide isolated from the marine cyanobacterium. </LI> <LI> Moderately cytotoxic against HeLa cells. </LI> <LI> Induced differentiation of neural stem cells into astrocytes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>