가족성 용종성 대장암 환자에서 발생한 공장암을 포함한 소화기계의 이시성 원발성 삼중암 = CASE REPORT : Jejunal Adenocarcinoma as Part of Metachronous Triple Primary Cancers of the Digestive Tract in Patient with Hereditary Nonpolyposis Colorectal Cancer

다국어 초록 (Multilingual Abstract)

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant inherited disease characterized by onset at a relatively early age, an excess of synchronous and metachronous tumors, and a variety of extracolorectal malignancies. Small bowel carcinoma reported, is included in the tumor spectrum of HNPCC, but the frequency of occurrence of this tumor in HNPCC patients is comparatively rare. In Korea, several cases of multiple primary cancers in patients with HNPCC have been reported, however, primary jejunal adenocarcinoma in conjunction with multiple primary cancers in the digestive tract has rarely been reported. Recently, we evaluated a 61-year-old male diagnosed with metachronous triple primary cancers of the jejunum, stomach, and colon. We report this rare case of primary jejunal adenocarcinoma as a part of metachronous triple cancers along with a review of the relevant literature. (Intest Res 2011;9:158-161)

참고문헌 (Reference)

1 Sijmons RH, "Vasen HF. Urinary tract cancer and hereditary nonpolyposis colorectal cancer: risks and screening options" 160 : 466-470, 1998

2 Schouten JP, "Relative quantification of 40 nucleic acid sequences by multiples ligation-dependent probe amplification" 30 : e57-, 2002

3 Gruber SB, "New developments in Lynch syndrome (hereditary nonpolyposis colorectal cancer) and mismatch repair gene testing" 130 : 577-587, 2006

4 Peltomäki P, "Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome" 53 : 5853-5855, 1993

5 Söreide K, "Microsatellite instability in colorectal cancer" 93 : 395-406, 2006

6 Baichi MM, "Metachronous small bowel adenocarcinomas detected by capsule endoscopy in a patient with hereditary nonpolyposis colorectal cancer" 52 : 1134-1136, 2007

7 ten Kate GL, "Kleibeuker JH, Nagengast FM, et al. Is surveillance of the small bowel indicated for Lynch syndrome families" 56 : 1198-1201, 2007

8 Overman MJ, "Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine" 102 : 144-150, 2010

9 Classics in oncology, "Heredity with reference to carcinoma as shown by the study of the cases examined in the pathological laboratory of the University of Michigan, 1895-1913. By Aldred Scott Warthin. 1913" 35 : 348-359, 1985

10 Park JG, "Hereditary colorectal cancer" 45 : 78-87, 2005

11 Schulmann K, "HNPCC-associated small bowel cancer: clinical and molecular characteristics" 128 : 590-599, 2005

12 "Gastrointestinal: synchronous and metachronous colorectal cancers" 18 : 457-, 2003

13 Aarnio M, "Cancer risk in mutation carriers of DNA-mismatch-repair genes" 81 : 214-218, 1999

14 Lynch HT, "Cancer family “G” revisited: 1895-1970" 27 : 1505-1511, 1971

15 Mcilvried DE, "Atypical identification of Lynch syndrome by immunohistochemistry and microsatellite instability analysis on jejunal adenocarcinoma" 9 : 377-381, 2010