Decrease in Plasma Adiponectin Concentrations in Patients with Vasospastic Angina

다국어 초록 (Multilingual Abstract)

Background and Objectives：Plasma adiponectin, which decreases the progression of atherosclerosis and insulin resistance, as well as suppressing lipid accumulation in macrophages, is decreased in patients with acute myocardial infarction and unstable angina pectoris; however, the correlation between plasma adiponectin and vasospastic angina pectoris (VAP) remains to be verified. We compared the plasma adiponectin concentration between patients with VAP and other coronary artery diseases; moreover, we investigated the association between the plasma adiponectin concentration and VAP. Subjects and Methods：Following coronary angiography for the evaluation of chest pain, 395 subjects (180 women and 215 men) were divided into 4 groups: acute coronary syndrome (ACS)(n=117), VAP (n=94), stable angina pectoris (SAP)(n=108) and angiographically normal coronary artery (n=76). The acetylcholine provocation test was used to confirm VAP, and plasma adiponectin concentrations were measured in all participants. Results：The plasma adiponectin concentrations in patients with VAP and ACS were significantly lower than that of the normal coronary artery group (6.6±5.4 vs. 5.2±4.0 vs. 9.0±6.2 μg/mL, p<0.001, respectively). A multivariate analysis indicated that plasma adiponectin [odd ratio (OR) 0.744, 95% confidence interval (CI) 0.645 to 0.858, p=0.001], smoking (OR 2.054, 95% CI 1.027 to 4.106, p=0.042) and age (OR 0.966, 95% CI 0.935 to 0.997, p=0.031) were independently correlated in patients diagnosed with VAP. Conclusion：Our results suggest that a decreased plasma adiponectin concentration may be associated with VAP. (Korean Circulation J 2006;36:255-260)

참고문헌 (Reference)

1 "cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1)." 221 : 286-289, 1996

2 "and coronary artery spasm in young women" 757-61,

3 "Unstable angina:a classification" 80 : 410-4, 1989

4 "The risk factors of vasospastic angina" 32 : 224-232, 2002

5 "Role of adiponectin in preventing vascular stenosis:the missing link of adipo-vascular axis" 277 : 37487-37491, 2002

6 "Prinzmetal's variant angina" 21 : 243-246, 1998

7 "Paradoxical decrease of an adipocyte specific protein,adiponectin,in obesity" 257 : 79-83, 1999

8 "Novel modulator for endothelial adhesion molecules:adipocyte-derived plasma protein adiponectin" 100 : 2473-2476, 1999

9 "Morphologic differences in the vessel wall at sites of focal and diffuse coronary vasospasm by intravascular ultrasound(IVUS)" 31 : 749-756, 2001

10 "Mental stress test is an effective inducer of vasospastic angina pectoris:comparison with cold pressor,hyperventilation and master two-step exercise test" 70 : 155-163, 1999

11 "Lesion severity and hypercholesterolemia determine long-term prognosis of vasospastic angina treated with calcium channel antagonists" 67 : 1029-1035, 2003

12 "Implications of plasma concentrations of adiponectin in patients with coronary artery disease" 90 : 528-533, 2004

13 "Impaired endothelium-dependent vasodilation in the brachial artery in variant angina pectoris and the effect of intravenous administration of vitamin C" 87 : 1154-1159, 2001

14 "Heart period variability in patients with variant angina" 77 : 932-936, 1996

15 "Endothelial dysfunction in the absence of coronary atheroma causing Prinzmetal's angina" 77 : 1997

16 "Elevated serum homocysteine in patients with coronary vasospasm" 34 : 53-58, 2004

17 "Decreased plasma adiponectin concentration in patients with essential hypertension" 16 : 72-75, 2003

18 "Association of hypoadiponectinemia with impaired vasoreactivity" 42 : 231-234, 2003

19 "Angiotensin II receptor blocker prevents increased arterial stiffness in patients with essential hypertension" 68 : 1194-1198, 2004

20 "An adipocyte-derived plasma protein,adiponectin adheres to injuried vascular walls" 32 : 47-50, 2000

21 "Adiponectin,adipocyte-derived plasma protein,inhibits endothelial NF-kB signaling through camp-dependent pathway" 102 : 1296-1301, 2000

22 "Adiponectin as a biomarker of the metabolic syndrome" 68 : 975-981, 2004

23 "Adipocyte-derived plasma protein,adiponectin,suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages" 103 : 1057-1063, 2001