운동과 아디포넥틴, TNF-α와의 관계 = Relationship between exercise and adiponectin, TNF-α

다국어 초록 (Multilingual Abstract)

Adipokines has been used to describe the numerous adipocyte secretory products, which include Tumor Necrosis Factor(TNF)-α, Interleukin-6(IL-6), Leptin, Resistin, and Adiponectin. There is growing evidence that adipocyte scretory products are important determinants of insulin resistance, cardiovascular, through either circulating hormonal effect or local effects on the adipocyte.
The expression of adiponectin is low in rodent models or humans obesity of insulin resistance, cardiovascular and is accompanied by low muscle and liver lipid accumulation. adiponectin knockout mice develop severe insulin resistance in response to a high-fat diet, in association with higher levels of TNF-α and increased tissue lipid accumulation.
TNF-α is considered as an important mediator of insulin resistance. However, the effect of TNF-α in skeletal muscle is still controversial. It has been shown, on one hand, that muscle TNF-α may play an important role in the development of insulin resistance in rat and humans. on the other hand it has also been reported that TNF-α may up-regulate glucose uptake in human muscle cells.
Physical exercise is a well established method for the treatment of insulin resistance and type 2 diabetes mellitus and atherosclerosis. Adiponectin and TNF-α is associated with insulin resistance, cardiovascular and because it is know to respond to exercise

목차 (Table of Contents)

• Ⅰ. 서론
• Ⅱ. 아디포카인(Adipokines)
• Ⅲ. 아디포넥틴(Adiponectin)
• 1. 아디포넥틴과 인슐린 저항성
• 2. 아디포넥틴과 심혈관질환
• 3. 아디포넥틴과 운동
• Ⅳ. 종양괴사인자-α(Tumorur Necrosis Factor-alpha)
• 1. TNF-α와 인슐린 저항성
• 2. TNF-α와 심혈관 질환
• 3. TNF-α와 운동
• Ⅴ. 논의 및 결론
• 참고문헌
• Abstract