A case of multiple cutaneous leiomyomas = A case of multiple cutaneous leiomyomas

다국어 초록 (Multilingual Abstract)

Cutaneous leiomyomas (CL) are benign smooth muscle tumors, which are also called as piloleiomyomas. CL may occur sporadically or as a cutaneous manifestation of an autosomal dominant genetic syndrome, hereditary leiomyomatosis and renal cell cancer (HLRCC), which was revealed to be associated with fumarate hydratase (FH) gene. HLRCC is associated with multiple CL and uterine leiomyomas in females, and renal cancers. CL may occur more often (76 to 100%) in individuals with the mutation of FH gene than renal cell cancer (about 15 to 20%). HLRCCassociated renal cancers are aggressive, so that dermatological diagnosis of CL is important for renal cancer screening. If possible, genetic study of FH mutation should be considered in individuals with multiple CL. Herein, we report a case of 59-year-old woman who presented painful multiple nodules and papules on her chest and right shoulder. She had a history of hysterectomy 16 years ago due to uterine leiomyoma. From skin biopsy, the specimen showed a wellcircumscribed nodular tumor within the reticular dermis. It presented interlacing bundles of tumor cells with blunt-ended or cigar-shaped nuclei. Tumor cells were positive for SMA, but they were S-100 negative. Finally, the cutaneous lesion was diagnosed as leiomyoma.