Bioactive Glass(BiogranⓇ)를 이용한 백서 두개골 결손부 수복에 관한 조직학적 연구 = A STUDY FOR HISTOLOGIC REACTION AFTER IMPLANTATION OF BIOACTIVE GLASS(BIOGRANⓇ) ON THE CRANIUM OF WHITE RATA STUDY FOR HISTOLOGIC REACTION AFTER IMPLANTATION OF BIOACTIVE GLASS(BIOGRANⓇ) ON THE CRANIUM OF WHITE RAT

다국어 초록 (Multilingual Abstract)

Various synthetic alloplast for repair of bone defect has been progressed and climcally applicated during recent 20 years. Silica glasses and glass ceramics have been shown to be both osteoconductive and biocompatible since 1972, and previous studies indicate that bioactive glasses and glass ceramics can be used as a bone substitute material alternative to autogenous and allogenous bone. These synthetic alloplastic materials may be widly applied to the oral and maxillofacial region m case of being taken over the disadvantage such as difficulty in processing, high cost, low processing efficieny, for these materials don t have disadvantages such as a pressure of double operations, postoperative pain, difficulty in finding out of donor. The purpose of this study ts searching for possibility of clinical application of bioactive glass powder of diameter 300~355nm after filling on the rat cranial CSD in comparison of repair capacity with clinically available decalcified freeze dried bone powder, histopathologically. We used 45 Rats(Sprague-Dowley) with approximate body weight of 250g, 15rats for practice group and 15 rats for control group. We made cranial bone defect, 15 on of allogenic bone, diameter of 8mm with drill and periosteal elevator In practice group, we filled bioactive glass commercially available(BiogranⓇ, Orthovita, Inc, U.S.A.) and in control group, we filled decalcified freeze dried bone powder obtained from limb bone of collecting group by the method of Reddi and Huggins. Animals were killed after 12weeks with internal fixation and decalcified, about 1cm resection block was embeaded in paraffin. We analyzed degree of bony healing and bone remodelling with light microscope after Hematoxylin-Eosin staining. The results after experimental study of implant of bioactive glass(BiogranⓇ) known for bone substitute material on 45 Rats(Sprague-Dowely) with approximate body weight of 250g are as follows. 1. Grafted DFDB showed more effective osteoconduction and new bone formation than bioactive glass after 3months. 2. Grafted bioactive glass showed active foreign body reaction after 3months. 3. Amorphous eosinophilic material partially substituted each of the inner and outer surface of the bioactive glass particle.

목차 (Table of Contents)

• Abstract
• Ⅰ. 서론
• Ⅱ. 연구재료 및 방법
• Ⅲ. 연구 결과
• IV. 총괄 및 고찰
• V. 결론
• 참고문헌