<P><B>Abstract</B></P> <P>Developing effective mucosal subunit vaccine for the <I>Streptococcus pneumoniae</I> has been unsuccessful mainly because of their poor immunogenicity with insufficient memory T and ...
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https://www.riss.kr/link?id=A107737942
2019
-
SCOPUS,SCIE
학술저널
362-372(11쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P><B>Abstract</B></P> <P>Developing effective mucosal subunit vaccine for the <I>Streptococcus pneumoniae</I> has been unsuccessful mainly because of their poor immunogenicity with insufficient memory T and ...
<P><B>Abstract</B></P> <P>Developing effective mucosal subunit vaccine for the <I>Streptococcus pneumoniae</I> has been unsuccessful mainly because of their poor immunogenicity with insufficient memory T and B cell responses. We thus address whether such limitation can be overcome by introducing effective adjuvants that can enhance immunity and show here that polysorbitol transporter (PST) serves as a mucosal adjuvant for a subunit vaccine against the <I>Streptococcus pneumoniae</I>. Pneumococcal surface protein A (PspA) with PST adjuvant induced protective immunity against <I>S. pneumoniae</I> challenge, especially long-term T and B cell immune responses. Moreover, we found that the PST preferentially induced T helper (Th) responses toward Th2 or T follicular helper (Tfh) cells and, importantly, that the responses were mediated through antigen-presenting cells via activating a peroxisome proliferator-activated receptor gamma (PPAR-γ) pathway. Thus, these data indicate that PST can be used as an effective and safe mucosal vaccine adjuvant against <I>S. pneumoniae</I> infection.</P> <P><B>State of Significance</B></P> <P>In this study, we suggested the nanoparticle forming adjuvant, PST works as an effective adjuvant for the pneumococcal vaccine, PspA. The PspA subunit vaccine together with PST adjuvant efficiently induced protective immunity, even in the long-term memory responses, against <I>Streptococcus pneumoniae</I> lethal challenge. We found that PspA with PST adjuvant induced dendritic cell activation followed by follicular helper T cell responses through PPAR-γ pathway resulting long-term memory antibody-producing cells. Consequently, in this paper, we suggest the mechanism for safe nanoparticle forming subunit vaccine adjuvant against pneumococcal infection.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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