Stent Thrombosis in the Era of the Drug-Eluting Stent

다국어 초록 (Multilingual Abstract)

Coronary stent thrombosis (ST) has been regarded as a rare but catastrophic complication of bare-metal stent(BMS) implantation that normally occurs during the first few weeks after stenting. In the drug-eluting stent (DES)era, there has been increasing concern regarding higher rates of ST due to delayed endothelialization. However, apooled meta-analysis of randomized clinical trials and registry studies showed rates of ST (0.4-1.5%) after DES tobe similar to those of BMS. The rate of ST did not differ between sirolimus- and paclitaxel-eluting stents. Additionally,the rates of late ST were similar between DES and BMS. Remarkably, very late occurrence of ST, which developsup to 1-2 years after DES implantation, was significantly associated with complete cessation of antiplatelet therapy.Further large-scale studies are needed to determine the optimal combination and duration for antiplatelet therapyin order to prevent these serious thrombotic events.

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