<P><B>Abstract</B></P> <P>With increasing demands on drug delivery <I>via</I> a transdermal route, there is a therapeutic and regulatory need for on-demand dosage control. Ideally, on-demand dose control woul...
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https://www.riss.kr/link?id=A107472895
2018
-
SCI,SCIE,SCOPUS
학술저널
18-26(9쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P><B>Abstract</B></P> <P>With increasing demands on drug delivery <I>via</I> a transdermal route, there is a therapeutic and regulatory need for on-demand dosage control. Ideally, on-demand dose control woul...
<P><B>Abstract</B></P> <P>With increasing demands on drug delivery <I>via</I> a transdermal route, there is a therapeutic and regulatory need for on-demand dosage control. Ideally, on-demand dose control would be based on a low-cost, scalable mechanical mechanism without the requirement for ancillary equipment. In this study, we report a touch-actuated transdermal delivery (TATD) patch which provides quantitative permeation control by the degree of mechanical pressing. The patch contains a refillable drug solution reservoir, strain sensor, and drug chamber with an array of microneedles. Mathematical functions are used to predict the normal force applied to the drug reservoir, drug solution released into the drug chamber, and amount of the permeated drug. The final relationship between permeation level and normal force is expressed as a simple equation, which allows for the precise control of drug permeation <I>via</I> external mechanical stimulation. This relationship is demonstrated by image analysis of the permeated drug through animal skin tissue. The TATD patch offers a suitable platform for on-demand control of therapeutic delivery in wearable healthcare systems.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A touch-actuated transdermal delivery (TATD) patch providing quantitative permeation control by mechanical pressing has been developed. </LI> <LI> Mathematical functions are used to predict the normal force applied to the drug reservoir, drug solution released into the drug chamber, and amount of the permeated drug. </LI> <LI> The relationships are clarified by release tests and <I>ex vivo</I> skin penetration tests <I>via</I> the permeated drug through animal skin tissue. </LI> </UL> </P>
Centrifugal microfluidic system for a fully automated N-fold serial dilution