PLGA/DBP지지체에 파종된 신경계세포가 골수간엽줄기세포의 분화와 증식에 미치는 영향 = Effect of PLGA/DBP Scaffolds Seeded OECs and SCs on the Proliferation and Differentiation of BMSCs

다국어 초록 (Multilingual Abstract)

Poly(lactic-co-glycolic acid)(PLGA) is a biodegradable synthetic polymer with acceptable mechanical strength and has well-controlled degradation rate. Demineralized bone particle(DBP) contains powerful bioactive molecules. Bone marrow mesenchymal stem cells(BMSCs) are important progenitor and supporting cells that have the intrinsic ability to self-renewal and differentiate into multiple functional cells. In this study, we fabricated natural/synthetic hybrid PLGA scaffolds included 20% of DBP(PLGA/DBP). Schwann cells(SCs) and olfactory ensheathing cells(OECs) were seeded on PLGA/DBP scaffolds. We confirmed that effects of PLGA/DBP scaffolds seeded OEC and SC on proliferation and differentiation of BMSCs. PLGA/DBP scaffolds seeded OECs and SCs were superior to differentiation into neuronal cell proliferation of BMSCs. This phenomenon was expected due to cytokine secreted by OECs and SCs promote proliferation and differentiation of BMSCs.