Savory Cracker Development for Blood Glucose Control and Management: Glycogen Storage Diseases

다국어 초록 (Multilingual Abstract)

The blood glucose response of savory slow energy-release crackers (GLY-HYP) were evaluated in volunteerscarrying glycogen storage diseases (GSDs), Types I (Ia) and IV. The crackers have been shown previously to provide a ‘‘flat’’slow glucose response in healthy volunteers, for up to 4 h. On average for the mixed-sex volunteer group aged 53 to 70 forType I, the blood glucose concentration increased from baseline to a maximum of 9.5 mmol/L at 60 min and remained abovebaseline for up to 210 min; overall, above 5 mmol/L for 4 h. In common with healthy individuals, a relatively flat bloodglucose response was recorded. For Type IV, mixed-sex patients aged between 55 and 72, the blood glucose concentrationreached maximum of 10.2 mmol/L at 45 min and then stayed above baseline for 150 min. Again, overall, above 5 mmol/L for4 h. Altogether, these data indicate that these crackers would provide a valuable contribution to the nutritional needs of peopleof different age groups with GSDs (Clinical Registration Number: HRC10032021).