1 Lutz BM, "mTOR, a new potential target for chronic pain and opioid-induced tolerance and hyperalgesia" 11 : 32-, 2015
2 Cui J, "mTOR pathway is involved in ADP-evoked astrocyte activation and ATP release in the spinal dorsal horn in a rat neuropathic pain model" 275 : 395-403, 2014
3 Lisi L, "mTOR kinase : a possible pharmacological target in the management of chronic pain" 2015 : 2015
4 Liang L, "mTOR and its downstream pathway are activated in the dorsal root ganglion and spinal cord after peripheral inflammation, but not after nerve injury" 1513 : 17-25, 2013
5 Yang X, "The role of MAPK and dopaminergic synapse signaling pathways in antidepressant effect of electroacupuncture pretreatment in chronic restraint stress rats" 2017 : 2017
6 Hunskaar S, "The formalin test in mice : dissociation between inflammatory and non-inflammatory pain" 30 : 103-114, 1987
7 Tjølsen A, "The formalin test : an evaluation of the method" 51 : 5-17, 1992
8 Gamaro GD, "The effects of acute and repeated restraint stress on the nociceptive response in rats" 63 : 693-697, 1998
9 Barrot M, "Tests and models of nociception and pain in rodents" 211 : 39-50, 2012
10 Asiedu MN, "Targeting AMPK for the alleviation of pathological pain" 107 : 257-285, 2016
1 Lutz BM, "mTOR, a new potential target for chronic pain and opioid-induced tolerance and hyperalgesia" 11 : 32-, 2015
2 Cui J, "mTOR pathway is involved in ADP-evoked astrocyte activation and ATP release in the spinal dorsal horn in a rat neuropathic pain model" 275 : 395-403, 2014
3 Lisi L, "mTOR kinase : a possible pharmacological target in the management of chronic pain" 2015 : 2015
4 Liang L, "mTOR and its downstream pathway are activated in the dorsal root ganglion and spinal cord after peripheral inflammation, but not after nerve injury" 1513 : 17-25, 2013
5 Yang X, "The role of MAPK and dopaminergic synapse signaling pathways in antidepressant effect of electroacupuncture pretreatment in chronic restraint stress rats" 2017 : 2017
6 Hunskaar S, "The formalin test in mice : dissociation between inflammatory and non-inflammatory pain" 30 : 103-114, 1987
7 Tjølsen A, "The formalin test : an evaluation of the method" 51 : 5-17, 1992
8 Gamaro GD, "The effects of acute and repeated restraint stress on the nociceptive response in rats" 63 : 693-697, 1998
9 Barrot M, "Tests and models of nociception and pain in rodents" 211 : 39-50, 2012
10 Asiedu MN, "Targeting AMPK for the alleviation of pathological pain" 107 : 257-285, 2016
11 Madrigal JL, "Stress-induced oxidative changes in brain" 5 : 561-568, 2006
12 Vaccarino AL, "Stress-induced analgesia prevents the development of the tonic, late phase of pain produced by subcutaneous formalin" 572 : 250-252, 1992
13 Pezalla PD, "Stress-induced analgesia in frogs : evidence for the involvement of an opioid system" 296 : 356-360, 1984
14 Amit Z, "Stress-induced analgesia : adaptive pain suppression" 66 : 1091-1120, 1986
15 Butler RK, "Stress-induced analgesia" 88 : 184-202, 2009
16 Reuter S, "Oxidative stress, inflammation, and cancer: how are they linked?" 49 : 1603-1616, 2010
17 Xu JT, "Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia" 124 : 592-603, 2014
18 Ma W, "Injured nerve-derived COX2/PGE2 contributes to the maintenance of neuropathic pain in aged rats" 31 : 1227-1237, 2010
19 Kwon M, "Inhibition of mammalian target of rapamycin(mTOR)signaling in the insular cortex alleviates neuropathic pain after peripheral nerve injury" 10 : 79-, 2017
20 Grassmé H, "Inhibition of acid sphingomyelinase by antidepressants counteracts stress-induced activation of P38-kinase in major depression" 23 : 84-92, 2015
21 Porro CA, "Immobilization and restraint effects on pain reactions in animals" 32 : 289-307, 1988
22 Niswander JM, "Hyperosmotic stressinduced caspase-3 activation is mediated by p38 MAPK in the hippocampus" 1186 : 1-11, 2007
23 Sakai S, "Heat stress affects prostaglandin synthesis in bovine endometrial cells" 64 : 311-317, 2018
24 Hunskaar S, "Formalin test in mice, a useful technique for evaluating mild analgesics" 14 : 69-76, 1985
25 Horan P, "Extremely long-lasting antagonistic actions of nor-binaltorphimine(nor-BNI)in the mouse tail-flick test" 260 : 1237-1243, 1992
26 Kim SK, "Expression levels of the hypothalamic AMPK gene determines the responsiveness of the rats to electroacupuncture-induced analgesia" 14 : 211-, 2014
27 Bayir H, "Enhanced oxidative stress in iNOS-deficient mice after traumatic brain injury : support for a neuroprotective role of iNOS" 25 : 673-684, 2005
28 Ge A, "Effects of metformin on the expression of AMPK and STAT3 in the spinal dorsal horn of rats with neuropathic pain" 17 : 5229-5237, 2018
29 Xu J, "Effects of electroacupuncture on chronic unpredictable mild stress rats depression-like behavior and expression of p-ERK/ERK and p-P38/P38" 2015 : 650729-, 2015
30 Fazli-Tabaei S, "Dopamine receptor mechanism(s)and antinociception and tolerance induced by swim stress in formalin test" 17 : 341-347, 2006
31 Ma W, "Does COX2-dependent PGE2 play a role in neuropathic pain?" 437 : 165-169, 2008
32 Young-Jun Seo, "Differential Cross-tolerance Development between Single and Repeated Immobilization Stress on the Antinociceptive Effect Induced by β- Endorphin, 5-Hydroxytryptamine, Morphine, and WIN55,212-2 in the Inflammatory Mouse Pain Model" 대한약학회 34 (34): 269-280, 2011
33 Jia-Piao Lin, "Dexmedetomidine Attenuates Neuropathic Pain by Inhibiting P2X7R Expression and ERK Phosphorylation in Rats" 한국뇌신경과학회 27 (27): 267-276, 2018
34 Kim KW, "Development of antinociceptive tolerance and changes of opioid receptor ligand binding in central nervous system of the mouse forced to single and repeated swimming in the cold water" 61 : 93-97, 2003
35 Seo YJ, "Changes in pain behavior induced by formalin, substance P, glutamate and pro-inflammatory cytokines in immobilization-induced stress mouse model" 71 : 279-286, 2006
36 Lerouet D, "Changes in oxidative stress, iNOS activity and neutrophil infiltration in severe transient focal cerebral ischemia in rats" 958 : 166-175, 2002
37 Vardeh D, "COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice" 119 : 287-294, 2009
38 Chen J, "C/EBP{beta} and its binding element are required for NF{kappa}B-induced COX2 expression following hypertonic stress" 280 : 16354-16359, 2005
39 Pavlovic Z, "Antinociceptive and hypothermic crosstolerance between continuous and intermittent cold-water swims in rats" 54 : 1081-1084, 1993
40 Heidari-Oranjaghi N, "Antagonism of orexin-1 receptors attenuates swim-and restraint stress-induced antinociceptive behaviors in formalin test" 103 : 299-307, 2012
41 Mizushima T, "Activation of p38MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia" 113 : 51-60, 2005
42 Imbe H, "Activation of mitogen-activated protein kinase in descending pain modulatory system" 2011 : 468061-, 2011
43 Zhang W, "Activation of mTOR in the spinal cord is required for pain hypersensitivity induced by chronic constriction injury in mice" 111 : 64-70, 2013
44 Gao YJ, "Activation of JNK pathway in persistent pain" 437 : 180-183, 2008
45 Koster R, "Acetic acid for analgesic screening" 18 : 412-, 1959