1 Going JJ, "‘Senescence-associated’ beta-galactosidase activity in the upper gastrointestinal tract" 196 : 394-400, 2002
2 de Keizer PL, "p53: pro-aging or pro-longevity?" 2 : 377-379, 2010
3 Freund A, "p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype" 30 : 1536-1548, 2011
4 Bazarov AV, "p16(INK4a)-mediated suppression of telomerase in normal and malignant human breast cells" 9 : 736-746, 2010
5 Mah LJ, "gammaH2AX: a sensitive molecular marker of DNA damage and repair" 24 : 679-686, 2010
6 Rabien A, "Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells" 103 : 169-175, 2012
7 Coppe JP, "Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype" 286 : 36396-36403, 2011
8 Waaijer ME, "The number of p16INK4a positive cells in human skin reflects biological age" 11 : 722-725, 2012
9 Hayflick L, "The limited in vitro lifetime of human diploid cell strains" 37 : 614-636, 1965
10 Cheung AL, "Telomere dysfunction, genome instability and cancer" 13 : 2075-2090, 2008
1 Going JJ, "‘Senescence-associated’ beta-galactosidase activity in the upper gastrointestinal tract" 196 : 394-400, 2002
2 de Keizer PL, "p53: pro-aging or pro-longevity?" 2 : 377-379, 2010
3 Freund A, "p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype" 30 : 1536-1548, 2011
4 Bazarov AV, "p16(INK4a)-mediated suppression of telomerase in normal and malignant human breast cells" 9 : 736-746, 2010
5 Mah LJ, "gammaH2AX: a sensitive molecular marker of DNA damage and repair" 24 : 679-686, 2010
6 Rabien A, "Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells" 103 : 169-175, 2012
7 Coppe JP, "Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype" 286 : 36396-36403, 2011
8 Waaijer ME, "The number of p16INK4a positive cells in human skin reflects biological age" 11 : 722-725, 2012
9 Hayflick L, "The limited in vitro lifetime of human diploid cell strains" 37 : 614-636, 1965
10 Cheung AL, "Telomere dysfunction, genome instability and cancer" 13 : 2075-2090, 2008
11 Feldser DM, "Telomere dysfunction and the initiation of genome instability" 3 : 623-627, 2003
12 Frias C, "Telomere dysfunction and genome instability" 17 : 2181-2196, 2012
13 Davalos AR, "Senescent cells as a source of inflammatory factors for tumor progression" 29 : 273-283, 2010
14 Krizhanovsky V, "Senescence of activated stellate cells limits liver fibrosis" 134 : 657-667, 2008
15 Fitzner B, "Senescence determines the fate of activated rat pancreatic stellate cells" 16 : 2620-2630, 2012
16 Xue W, "Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas" 445 : 656-660, 2007
17 Yao H, "Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD" 303 : L557-L566, 2012
18 Froeling FE, "Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-beta-catenin signaling to slow tumor progression" 141 : 1486-1497, 2011
19 Ventura A, "Restoration of p53 function leads to tumour regression in vivo" 445 : 661-665, 2007
20 David G, "Regulation of oncogene-induced cell cycle exit and senescence by chromatin modifiers" 13 : 992-1000, 2012
21 Debacq-Chainiaux F, "Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo" 4 : 1798-1806, 2009
22 Xu Q, "Overexpression of the DEC1 protein induces senescence in vitro and is related to better survival in esophageal squamous cell carcinoma" 7 : e41862-, 2012
23 Wajapeyee N, "Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7" 132 : 363-374, 2008
24 Peltomaki P, "Mutations and epimutations in the origin of cancer" 318 : 299-310, 2012
25 Macgregor-Das AM, "Molecular pathways in pancreatic carcinogenesis" 107 : 8-14, 2013
26 Quintas-Cardama A, "Molecular biology of bcr-abl1-positive chronic myeloid leukemia" 113 : 1619-1630, 2009
27 Vanuytsel T, "Major signaling pathways in intestinal stem cells" 1830 : 2410-2426, 2012
28 Watts G, "Leonard Hayflick and the limits of ageing" 377 : 2075-, 2011
29 Freund A, "Lamin B1 loss is a senescence-associated biomarker" 23 : 2066-2075, 2012
30 Chiantore MV, "Interferon-beta induces cellular senescence in cutaneous human papilloma virus-transformed human keratinocytes by affecting p53 transactivating activity" 7 : e36909-, 2012
31 Hasan MR, "Inhibition of VEGF induces cellular senescence in colorectal cancer cells" 129 : 2115-2123, 2011
32 Freund A, "Inflammatory networks during cellular senescence: causes and consequences" 16 : 238-246, 2010
33 Krizhanovsky V, "Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology" 73 : 513-522, 2008
34 Nakano A, "Immunohistochemical studies on the expression of P-glycoprotein and p53 in relation to histological differentiation and cell proliferation in hepatocellular carcinoma" 25 : 158-165, 2003
35 Wang Y, "High expression of p16INK4a and low expression of Bmi1 are associated with endothelial cellular senescence in the human cornea" 18 : 803-815, 2012
36 Wiemann SU, "Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis" 16 : 935-942, 2002
37 Corless CL, "Gastrointestinal stromal tumours: origin and molecular oncology" 11 : 865-878, 2011
38 Kuo LJ, "Gamma-H2AX: a novel biomarker for DNA double-strand breaks" 22 : 305-309, 2008
39 Tollervey JR, "Epigenetics: judge, jury and executioner of stem cell fate" 7 : 823-840, 2012
40 Goel A, "Epigenetics of colorectal cancer" 143 : 1442-1460, 2012
41 Galvani E, "Epidermal growth factor receptor tyrosine kinase inhibitors: current status and future perspective in the development of novel irreversible inhibitors for the treatment of mutant non-small cell lung cancer" 19 : 818-832, 2013
42 Moretti F, "Effects of exogenous p53 transduction in thyroid tumor cells with different p53 status" 85 : 302-308, 2000
43 Katz SF, "Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation" 142 : 1229-1239, 2012
44 Carriere C, "Deletion of Rb accelerates pancreatic carcinogenesis by oncogenic Kras and impairs senescence in premalignant lesions" 141 : 1091-1101, 2011
45 Rodier F, "DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion" 124 (124): 68-81, 2011
46 Nagaria P, "DNA double-strand break response in stem cells: mechanisms to maintain genomic integrity" 1830 : 2345-2353, 2013
47 Chen Z, "Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis" 436 : 725-730, 2005
48 Garagnani P, "Colorectal cancer microenvironment: among nutrition, gut microbiota, inflammation and epigenetics" 19 : 765-778, 2012
49 National Cancer Institute, "Colon and rectal cancer" Bethesda: National Cancer Institute at the National Institutes of Health
50 Campisi J, "Cellular senescence: when bad things happen to good cells" 8 : 729-740, 2007
51 Campisi J, "Cellular senescence: putting the paradoxes in perspective" 21 : 107-112, 2011
52 Rayess H, "Cellular senescence and tumor suppressor gene p16" 130 : 1715-1725, 2012
53 Breivik J, "Carcinogenesis and natural selection: a new perspective to the genetics and epigenetics of colorectal cancer" 76 : 187-212, 1999
54 Everhart JE, "Burden of digestive diseases in the United States. Part III: liver, biliary tract, and pancreas" 136 : 1134-1144, 2009
55 Oikonomou E, "BRAF(V600E) efficient transformation and induction of microsatellite instability versus KRAS(G12V) induction of senescence markers in human colon cancer cells" 11 : 1116-1131, 2009
56 "Association of TP53 Mutations With Stem Cell-Like Gene Expression and Survival of Patients With Hepatocellular Carcinoma" W B SAUNDERS CO-ELSEVIER INC 140 : 1063-U524, 2011
57 He L, "A microRNA component of the p53 tumour suppressor network" 447 : 1130-1134, 2007